Drugs / CDX-1140
last change May 2026 re-read 2 minutes ago

CDX-1140

Monoclonal antibody targets CD40 via activation

Developed for
epithelial neoplasm · non-small cell lung carcinoma · pancreatic adenocarcinoma · basal cell carcinoma · bile duct cancer · bone sarcoma · breast cancer · breast carcinoma
+37 more · cholangiocarcinoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · colorectal cancer · cutaneous neuroendocrine carcinoma · diffuse large B-cell lymphoma · endometrial serous adenocarcinoma · esophageal cancer · fallopian tube cancer · fallopian tube endometrioid adenocarcinoma · fallopian tube serous adenocarcinoma · follicular lymphoma · gastric cancer · head and neck cancer · Her2-receptor negative breast cancer · hypopharynx squamous cell carcinoma · laryngeal squamous cell carcinoma · malignant pancreatic neoplasm · MALT lymphoma · mantle cell lymphoma · melanoma · metastatic melanoma · nasal cavity squamous cell carcinoma · nasopharyngeal carcinoma · oral cavity squamous cell carcinoma · oropharynx squamous cell carcinoma · ovarian cancer · ovarian clear cell adenocarcinoma · ovarian endometrioid adenocarcinoma · ovarian serous adenocarcinoma · primary peritoneal carcinoma · primary peritoneal serous adenocarcinoma · renal cell carcinoma · skin squamous cell carcinoma · soft tissue sarcoma · urothelial carcinoma · uveal melanoma · Waldenstrom macroglobulinemia
Investigated by
Celldex Therapeutics · National Cancer Institute (NCI) · Merck Sharp & Dohme LLC · Providence Health & Services · Albert Einstein College of Medicine · Craig L Slingluff, Jr
+10 more · Gateway for Cancer Research · HiberCell, Inc. · National Cancer Institute (NCI) · National Institutes of Health (NIH) · Roswell Park Cancer Institute · The Foundation for Barnes-Jewish Hospital · United States Department of Defense · University of Southern California · University of Texas Southwestern Medical Center · Washington University School of Medicine

Trials 12 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT05349890 Apr 2023 → Apr 2027 expected epithelial neoplasm Providence Health & Services Active not recruiting No outcome recorded
Phase 1 NCT04616248 Jan 2023 → Jan 2027 expected basal cell carcinoma, bone sarcoma, breast carcinoma, cutaneous neuroendocrine carcinoma +3 University of Southern California Active not recruiting No outcome recorded
Phase 1 NCT05484011 Dec 2022 → Mar 2024 pancreatic adenocarcinoma HiberCell, Inc. Terminated No outcome recorded
Phase 1 NCT05029999 Apr 2022 → Apr 2028 expected Her2-receptor negative breast cancer University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 1 NCT04520711 Feb 2022 → Dec 2026 expected epithelial neoplasm Providence Health & Services Active not recruiting No outcome recorded
Phase 1 NCT03329950 Dec 2017 → Sep 2022 MALT lymphoma, Waldenstrom macroglobulinemia, breast cancer, cholangiocarcinoma +16 Celldex Therapeutics Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT05849480 May 2024 → Jun 2040 expected bile duct cancer National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT04491084 Jan 2021 → Aug 2022 non-small cell lung carcinoma Albert Einstein College of Medicine Terminated No outcome recorded
Phase 1/2 NCT04364230 Sep 2020 → Mar 2024 uveal melanoma Craig L Slingluff, Jr Completed No outcome recorded
Phase 23 trials
Phase 2 NCT06980038 May 2026 → Nov 2027 expected hypopharynx squamous cell carcinoma, laryngeal squamous cell carcinoma, nasal cavity squamous cell carcinoma, nasopharyngeal carcinoma +2 National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT05231122 Mar 2024 → Mar 2027 expected endometrial serous adenocarcinoma, fallopian tube endometrioid adenocarcinoma, fallopian tube serous adenocarcinoma, ovarian clear cell adenocarcinoma +3 Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 2 NCT04536077 Aug 2021 → Nov 2023 malignant pancreatic neoplasm Washington University School of Medicine Terminated No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as CDX-1140 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05349890
11

NCT05849480

NCT04536077

NCT04491084

NCT04616248

NCT05029999

NCT05231122

NCT06980038

NCT03329950

NCT05484011

NCT04364230

NCT04520711

Action Activate “agonistic CD40 antibody (CDX-1140)” PMID 41775435 Mar 2026
Modality Monoclonal antibody “CDX-1140 (CD40 antibody)” NCT03329950
Route Intravenous “single IV infusion” NCT04536077
Target CD40 “agonistic CD40 antibody (CDX-1140)” PMID 41775435 Mar 2026