Drugs / Mazdutide
last change Aug 2026 re-read 2 minutes ago

Mazdutide

English name mazdutide
also known as IBI362 · LY3305677 · Mazdutida

Protein / enzyme biologic targets GCGR via activation

Developed for
obesity disorder · type 2 diabetes mellitus · alcohol-related disorders · cognitive impairment with or without cerebellar ataxia · coronary atherosclerosis · dementia · diastolic heart failure · hypertensive disorder
+8 more · metabolic dysfunction-associated steatohepatitis · metabolic dysfunction-associated steatotic liver disease · mild heart failure · morbid obesity · NAFLD1 · obstructive sleep apnea syndrome · polycystic ovary syndrome · prediabetes syndrome
Investigated by
Innovent Biologics (Suzhou) Co. Ltd. · Eli Lilly and Company · Shanghai Zhongshan Hospital · Beijing Friendship Hospital · Changzhou No.2 People's Hospital · China National Center for Cardiovascular Diseases
+15 more · China-Japan Friendship Hospital · Huadong Hospital · Innovent Biologics, Inc. · Jiangsu Province Hospital of Traditional Chinese Medicine · Nanjing First Hospital, Nanjing Medical University · Shandong Provincial Hospital · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · The Second Affiliated Hospital of Dalian Medical University · Tianjin Fifth Central Hospital · Tianjin First Central Hospital · Tianjin Medical University · Tianjin TEDA Hospital · Tianjin Third Central Hospital · Xiangya Hospital of Central South University

Trials 35 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT06536023 Aug 2024 → Jul 2025 Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 1 NCT05793450 May → Sep 2023 impaired renal function disease Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 1 NCT05815680 Apr → Aug 2023 obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 1 NCT05623839 Nov 2022 → Jun 2023 obesity disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT04773977 Mar 2021 obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 1 NCT03928379 Oct 2019 → Jul 2021 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT03325387 Oct 2017 → Aug 2018 Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT02972645 Dec 2016 → Jul 2017 Eli Lilly and Company Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT07000955 Jun 2025 → Sep 2026 expected obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Active not recruiting No outcome recorded
Phase 1/2 NCT06519656 Oct 2024 → Dec 2025 overdue polycystic ovary syndrome Shanghai Zhongshan Hospital Recruiting No outcome recorded
Phase 1/2 NCT04466904 Sep 2020 → May 2021 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 1/2 NCT04440345 Jun 2020 → Jun 2021 obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 27 trials
Phase 2 NCT06937749 Jul 2025 → Apr 2026 overdue metabolic dysfunction-associated steatohepatitis Innovent Biologics (Suzhou) Co. Ltd. Recruiting No outcome recorded
Phase 2 NCT06862908 Apr 2025 → Sep 2026 expected diastolic heart failure, mild heart failure, obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Recruiting No outcome recorded
Phase 2 NCT06817356 Feb 2025 → Mar 2026 alcohol-related disorders Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT06124807 Nov 2023 → Jan 2025 obesity disorder Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT06143956 Nov 2023 → Sep 2027 expected obesity disorder Eli Lilly and Company Recruiting No outcome recorded
Phase 2 NCT04965506 Sep 2021 → Apr 2022 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 2 NCT04904913 Jun 2021 → Mar 2023 obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 310 trials
Phase 3 NCT07469800 Apr → Aug 2026 overdue hypertensive disorder, obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Recruiting No outcome recorded
Phase 3 NCT07255209 Dec 2025 → Oct 2027 expected Innovent Biologics (Suzhou) Co. Ltd. Recruiting No outcome recorded
Phase 3 NCT07083154 Sep 2025 → Aug 2029 expected cognitive impairment with or without cerebellar ataxia, dementia, type 2 diabetes mellitus The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting No outcome recorded
Phase 3 NCT06931028 Jun 2025 → May 2027 expected obesity disorder, obstructive sleep apnea syndrome Innovent Biologics (Suzhou) Co. Ltd. Recruiting No outcome recorded
Phase 3 NCT06884293 May 2025 → Dec 2026 expected metabolic dysfunction-associated steatotic liver disease, obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Active not recruiting No outcome recorded
Phase 3 NCT06184568 Feb 2024 → Sep 2025 obesity disorder, type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 3 NCT06164873 Dec 2023 → Jun 2025 overdue obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Active not recruiting No outcome recorded
Phase 3 NCT05628311 Jan → Oct 2023 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 3 NCT05606913 Jan 2023 → Jan 2024 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 3 NCT05607680 Nov 2022 → Aug 2023 obesity disorder Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 42 trials
Phase 4 NCT07654062 Jul 2026 → Jun 2028 expected prediabetes syndrome Shandong Provincial Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07657676 May 2026 → Oct 2027 expected coronary atherosclerosis, obesity disorder China National Center for Cardiovascular Diseases Not yet recruiting No outcome recorded
Phase not applicable4 trials
NCT07713992 Sep 2026 → Dec 2027 expected NAFLD1, type 2 diabetes mellitus Tianjin Medical University Not yet recruiting No outcome recorded
NCT07633639 May 2026 → May 2028 expected obesity disorder China-Japan Friendship Hospital Recruiting No outcome recorded
NCT07517042 Apr 2026 → Dec 2028 expected obesity disorder Shanghai Zhongshan Hospital Recruiting No outcome recorded
NCT07135141 Sep 2025 → Sep 2027 expected morbid obesity Beijing Friendship Hospital Not yet recruiting No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT07417306 Comparator Mar 2026 → Aug 2027 expected type 2 diabetes mellitus Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 38 sources stand behind the page.

FieldValueCited text
Known as Mazdutide Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist” PMID 36247927 Oct 2022
11

NCT07517042

NCT06817356

NCT07633639

NCT07654062

NCT07417306

NCT06124807

NCT07713992

NCT06519656

NCT07083154

NCT07657676

NCT07135141

Known as IBI362 “Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist” PMID 36247927 Oct 2022
20

“Mazdutide (IBI362) is a GLP-1 receptor/glucagon receptor (GLP-1R/GCGR) dual agonist.” NCT07654062

NCT04773977

NCT06184568

NCT04904913

NCT06536023

NCT06931028

NCT06884293

NCT07000955

NCT06937749

NCT06164873

NCT05606913

NCT05815680

NCT04965506

NCT05793450

NCT05628311

NCT07469800

NCT05607680

NCT04466904

NCT07255209

NCT06862908

Known as LY3305677 “We conducted a randomised, placebo-controlled phase 1b study (ClinicalTrials.gov: NCT04466904) to evaluate the safety and efficacy of IBI362 (LY3305677), a GLP-1 and glucagon...” PMID 35750681 Jun 2022
6

“Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist” PMID 36247927 Oct 2022

NCT03928379

NCT03325387

NCT05623839

NCT02972645

NCT06143956

Known as Mazdutida ChEMBL registry synonym — accepted as the source's own label CHEMBL5095358
Action Activate “glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist” PMID 36247927 Oct 2022
Modality Protein / enzyme biologic CHEMBL5095358
Route Subcutaneous “Single escalating doses of LY3305677 administered subcutaneously (SC)” NCT02972645
Target GCGR “GLP-1R and GCGR dual agonist” NCT06519656