Drugs / Pranlukast
last change Sep 2011 re-read 9 days ago

Pranlukast

also known as Azlaire · CCN 00401 · ONO 1078 · Onon · RS 411 · SB 205312

Small molecule targets CYSLTR1 via inhibition

Developed for
chronic rhinosinusitis · perennial allergic rhinitis · seasonal allergic rhinitis
Investigated by
Ono Pharmaceutical Co., Ltd. · SamA Pharmaceutical Co., Ltd

Trials 2

200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 32 trials
Phase 3 NCT01539304 Sep 2010 → Aug 2011 perennial allergic rhinitis SamA Pharmaceutical Co., Ltd Completed No outcome recorded
Phase 3 NCT00410735 Dec 2006 → Jun 2008 chronic rhinosinusitis Ono Pharmaceutical Co., Ltd. Completed No outcome recorded
Comparator or background therapy1 trial
Phase 3 NCT00127647 Comparator Nov 2004 → Apr 2005 seasonal allergic rhinitis Organon and Co Completed Met primary

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Pranlukast “Pranlukast 10% dry syrup, b.i.d.” NCT01539304 ↗
2

NCT00410735 ↗

NCT00127647 ↗

Known as Azlaire ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as CCN 00401 ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as ONO 1078 ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as Onon ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as RS 411 ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as SB 205312 ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Action Inhibit “Cysteinyl leukotriene receptor 1 antagonist” CHEMBL21333 ↗
Modality Small molecule — CHEMBL21333 ↗
Route Oral “Montelukast 5mg, 10mg or pranlukast 450mg and the corresponding placebo were orally administered to patients with seasonal allergic rhinitis three times a day for 2 weeks.” PMID 18946234 ↗ Nov 2008
Target CYSLTR1 “Cysteinyl leukotriene receptor 1 antagonist” CHEMBL21333 ↗