Pranlukast

also known as Azlaire · CCN 00401 · ONO 1078 · Onon · RS 411 · SB 205312

Small molecule targets CYSLTR1 via inhibition

Developed for: chronic rhinosinusitis · perennial allergic rhinitis · seasonal allergic rhinitis
Investigated by: Ono Pharmaceutical Co., Ltd. · SamA Pharmaceutical Co., Ltd

today NCT01539304 · Ph 3 NCT00410735 · Ph 3

200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 3	NCT01539304	Sep 2010 → Aug 2011	perennial allergic rhinitis	SamA Pharmaceutical Co., Ltd	Completed	No outcome recorded
Phase 3	NCT00410735	Dec 2006 → Jun 2008	chronic rhinosinusitis	Ono Pharmaceutical Co., Ltd.	Completed	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 3	NCT00127647 Comparator	Nov 2004 → Apr 2005	seasonal allergic rhinitis	Organon and Co	Completed	No outcome recorded

Every value below carries the sentence it was read from. 5 sources stand behind the page.

Field	Value	Cited text
Known as	Pranlukast	“Pranlukast 10% dry syrup, b.i.d.” NCT01539304 ↗ 2 NCT00127647 ↗ NCT00410735 ↗
Known as	Azlaire	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as	CCN 00401	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as	ONO 1078	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as	Onon	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as	RS 411	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Known as	SB 205312	ChEMBL registry synonym — accepted as the source's own label CHEMBL21333 ↗
Action	Inhibit	“Cysteinyl leukotriene receptor 1 antagonist” CHEMBL21333 ↗
Modality	Small molecule	— CHEMBL21333 ↗
Route	Oral	“Montelukast 5mg, 10mg or pranlukast 450mg and the corresponding placebo were orally administered to patients with seasonal allergic rhinitis three times a day for 2 weeks.” PMID 18946234 ↗ Nov 2008
Target	CYSLTR1	“Cysteinyl leukotriene receptor 1 antagonist” CHEMBL21333 ↗