Drugs / PLICAMYCIN
PLICAMYCIN
also known as
Mithramycin · A-2371 · ANTIBIOTIC LA-7017 · Aureolic acid · LA-7017 · Mithracin · Mithramycin a · NSC-24559 · +3 more
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT02859415 | Aug → Dec 2019 | germ cell tumor, lung neoplasm, mesothelioma, neoplasm of esophagus +1 | National Cancer Institute (NCI) | Terminated | No outcome recorded Stop: Enrollment |
| Phase 1/2 | NCT01610570 | May 2012 → May 2014 | Ewing sarcoma | National Cancer Institute (NCI) | Terminated | No outcome recorded Stop: Enrollment |
| Phase 21 trial | ||||||
| Phase 2 | NCT01624090 | Sep 2012 → Aug 2019 | breast cancer, esophageal cancer, lung cancer, mesothelioma | National Cancer Institute (NCI) | Terminated | No outcome recorded Stop: Enrollment |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | PLICAMYCIN | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | A-2371 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | ANTIBIOTIC LA-7017 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | Aureolic acid | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | LA-7017 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | Mithracin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | Mithramycin | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01610570 ↗ |
| Known as | Mithramycin a | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | NSC-24559 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | PA-144 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | Plicamicina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Known as | Plicamycine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1237054 ↗ |
| Action | Inhibit | “mithramycin was identified as a potent inhibitor of the Ewing sarcoma EWS-FLI1 transcription factor.” PMID 28735378 ↗ Jul 2017 |
| Modality | Small molecule | — CHEMBL1237054 ↗ |
| Route | Intravenous | “Mithramycin was administered intravenously over 6 h once daily for 7 days for 28 day cycles.” PMID 28735378 ↗ Jul 2017 |