Drugs / ARRY-371797
last change Jul 2024 re-read 2 minutes ago

ARRY-371797

also known as PF-07265803

Small molecule

Developed for
dilated cardiomyopathy 1A · ankylosing spondylitis · dilated cardiomyopathy · osteoarthritis, knee · rheumatoid arthritis
Investigated by
Pfizer · Array BioPharma

Trials 9 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00790049 Oct 2008 → Jan 2009 Array BioPharma Completed No outcome recorded
Phase 1 NCT00729209 Jul 2008 → Apr 2009 rheumatoid arthritis Array BioPharma Completed No outcome recorded
Phase 26 trials
Phase 2 NCT02351856 Feb 2015 → Dec 2020 dilated cardiomyopathy 1A Pfizer Completed No outcome recorded
Phase 2 NCT02057341 Feb 2014 → May 2016 dilated cardiomyopathy 1A Pfizer Completed No outcome recorded
Phase 2 NCT01366014 Jun 2011 → Jun 2012 osteoarthritis, knee Pfizer Completed No outcome recorded
Phase 2 NCT00811499 Dec 2008 → Sep 2009 ankylosing spondylitis Pfizer Terminated No outcome recorded
Phase 2 NCT00663767 Apr → Jun 2008 Pfizer Completed No outcome recorded
Phase 2 NCT00542035 Nov 2007 → Feb 2008 Pfizer Completed No outcome recorded
Phase 31 trial
Phase 3 NCT03439514 Apr 2018 → Oct 2022 dilated cardiomyopathy, laminopathy Pfizer Terminated No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

FieldValueCited text
Known as ARRY-371797 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00663767
8

NCT00542035

NCT02351856

NCT00790049

NCT01366014

NCT00811499

NCT02057341

NCT00729209

NCT03439514

Known as PF-07265803 “In a phase 2 trial and long-term extension, the selective p38α MAPK (mitogen-activated protein kinase) inhibitor, ARRY-371797 (PF-07265803), was associated with an improved...” PMID 38979608 Jul 2024
2

“ARRY-371797 (PF-07265803), a potent, selective, oral, small-molecule inhibitor of the p38α mitogen-activated protein kinase pathway” PMID 36114020 Sep 2022

“ARRY-371797 (PF-07265803)” NCT03439514

Action Inhibit “ARRY-371797, p38 inhibitor; oral” NCT00542035
Modality Small molecule “small-molecule inhibitor of the p38α mitogen-activated protein kinase pathway” PMID 36114020 Sep 2022
Route Oral “ARRY-371797, p38 inhibitor; oralNCT00542035