Drugs / Trimetrexate

Trials 13 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT00119301 Apr 2005 → Apr 2007 sarcoma Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT00002120 HIV infectious disease, pneumocystosis U.S. Bioscience Completed No outcome recorded
Phase 1 NCT00000998 ? → Apr 1989 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 22 trials
Phase 2 NCT00003776 Dec 1998 → Mar 2000 sarcoma Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2 NCT00002955 Aug 1995 → May 2000 malignant pancreatic neoplasm University of Southern California Completed No outcome recorded
Phase 36 trials
Phase 3 NCT00001016 ? → Aug 2007 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000724 ? → Jul 2004 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000714 ? → Jul 2004 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001014 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000730 ? → Mar 1989 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 3 NCT00001013 ? → Sep 1991 HIV infectious disease, pneumocystosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase not applicable2 trials
NCT00002102 HIV infectious disease, pneumocystosis U.S. Bioscience Completed No outcome recorded
NCT00002434 HIV infectious disease, pneumocystosis U.S. Bioscience Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as trimetrexate ClinicalTrials.gov intervention name — accepted as the source's own label NCT00119301
12

NCT00001013

NCT00000730

NCT00001016

NCT00001014

NCT00002434

NCT00000724

NCT00000998

NCT00000714

NCT00003776

NCT00002120

NCT00002955

NCT00002102

Known as TMTX “To study the safety and effectiveness of trimetrexate (TMTX) plus leucovorin calcium rescue (LCV) in the treatment of Pneumocystis carinii pneumonia (PCP) in patients who have...” NCT00000724
7

“To evaluate the safety and effectiveness of trimetrexate (TMTX) given at increasing doses along with the leucovorin calcium (LCV) for treating Pneumocystis carinii pneumonia...” NCT00000998

“Trimetrexate (TMTX) was chosen for this trial because it was found to be much more potent than sulfamethoxazole/trimethoprim (SMX/TMP) against the PCP organism in laboratory tests.” NCT00001013

“This study compares therapy with trimetrexate (TMTX) and leucovorin (LCV) to standard therapy and standard therapy plus high-dose steroids (methylprednisolone).” NCT00000730

“oral trimetrexate glucuronate (TMTX) and leucovorin calcium every 12 hours for 21 days (weeks 0-2)” NCT00003776

“investigational drug therapy (trimetrexate plus leucovorin calcium (TMTX / LCV))” NCT00000714

“investigational drug trimetrexate (TMTX) with leucovorin rescue (LCV)” NCT00001016

“trimetrexate glucuronate (TMTX)” NCT00002120

Known as trimetrexate glucuronate “oral trimetrexate glucuronate (TMTX) and leucovorin calcium every 12 hours for 21 days (weeks 0-2)” NCT00003776
Route Intravenous “Both drugs are given by intravenous infusion” NCT00000714