Drugs / ispinesib
last change Sep 2010 re-read 3 minutes ago

ispinesib

also known as SB-715992
Developed for
Burkitt lymphoma · grade III lymphomatoid granulomatosis · acute erythroid leukemia · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
+53 more · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · acute promyelocytic leukemia · acute undifferentiated leukemia · adult acute lymphoblastic leukemia · adult acute monocytic leukemia · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · breast cancer · breast neoplasm · cancer of unknown primary site · cerebellar astrocytoma · childhood brain stem glioma · childhood central nervous system germ cell tumor · childhood choroid plexus neoplasm · childhood medulloblastoma · childhood spinal cord tumor · chronic lymphocytic leukemia/small lymphocytic lymphoma · craniopharyngioma · cutaneous melanoma · grade II meningioma · grade III meningioma · Hodgkins lymphoma · hypopharynx squamous cell carcinoma · large-cell immunoblastic lymphoma · larynx verrucous carcinoma · liver cancer · low-grade astrocytoma · malignant colon neoplasm · MALT lymphoma · mantle cell lymphoma · metastatic malignant neoplasm in the colon · metastatic squamous cell carcinoma · myelodysplastic syndrome with excess blasts · nasal cavity and paranasal sinus squamous cell carcinoma · nodal marginal zone B-cell lymphoma · non-small cell lung carcinoma · oropharynx squamous cell carcinoma · ovarian cancer · pediatric high-grade glioma · pediatric infratentorial ependymoma · pediatric supratentorial ependymoma · precursor lymphoblastic lymphoma/leukemia · prostate adenocarcinoma · rectal carcinoma · refractory anemia with excess blasts in transformation · renal cell carcinoma · salivary gland cancer · splenic marginal zone lymphoma · supratentorial primitive neuroectodermal tumor · verrucous carcinoma of oral cavity · Waldenstrom macroglobulinemia
Investigated by
National Cancer Institute (NCI) · GlaxoSmithKline · NCIC Clinical Trials Group · Cytokinetics

Trials 14

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT00607841 Dec 2007 → Nov 2009 breast cancer Cytokinetics Terminated No outcome recorded
Phase 1 NCT00363272 Jun 2006 → Oct 2008 Burkitt lymphoma, cerebellar astrocytoma, childhood brain stem glioma, childhood central nervous system germ cell tumor +13 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00098826 Dec 2004 → May 2008 acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +13 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00101244 Nov 2004 → Feb 2010 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, Waldenstrom macroglobulinemia +7 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00119171 Nov 2004 → ? — GlaxoSmithKline Completed No outcome recorded
Phase 29 trials
Phase 2 NCT00354250 May 2006 → Feb 2007 renal cell carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00096499 Apr 2005 → Jan 2007 prostate adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00095992 Mar 2005 → Sep 2006 liver cancer NCIC Clinical Trials Group Completed No outcome recorded
Phase 2 NCT00095628 Jan 2005 → Jul 2010 hypopharynx squamous cell carcinoma, larynx verrucous carcinoma, metastatic squamous cell carcinoma, nasal cavity and paranasal sinus squamous cell carcinoma +3 National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00103311 Jan 2005 → Jan 2010 malignant colon neoplasm, metastatic malignant neoplasm in the colon, rectal carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00097409 Dec 2004 → May 2007 ovarian cancer GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT00095953 Nov 2004 → Sep 2006 cutaneous melanoma NCIC Clinical Trials Group Completed No outcome recorded
Phase 2 NCT00089973 Jun 2004 → Aug 2006 breast neoplasm GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT00085813 Dec 2003 → Oct 2005 non-small cell lung carcinoma GlaxoSmithKline Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as ispinesib ClinicalTrials.gov intervention name — accepted as the source's own label NCT00363272 ↗
13

NCT00101244 ↗

NCT00103311 ↗

NCT00119171 ↗

NCT00095953 ↗

NCT00098826 ↗

NCT00607841 ↗

NCT00095992 ↗

NCT00085813 ↗

NCT00096499 ↗

NCT00354250 ↗

Show 3 more sources

Known as SB-715992 “A Phase I/II Non-Randomized, Open-Label, Dose-Finding Study of Ispinesib (SB-715992) Followed By a Fixed-Dose Study in Chemotherapy-Naïve Patients With Metastatic Breast Cancer (MBC).” NCT00607841 ↗
1

“A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.” PMID 17962907 ↗ Oct 2007

Action Inhibit “To assess the response rate and toxicity of the kinesin spindle protein (KSP) inhibitor, ispinesib, in malignant melanoma.” PMID 17962907 ↗ Oct 2007
Route Intravenous “given intravenously (IV)” NCT00085813 ↗