Drugs / Gefapixant
Gefapixant
also known as
AF-219 · AF-219 CITRATE · Gefapixant Citrate · Lyfnua · MK-7264 · MK-7264 CITRATE · R-1646 · RG-1646 · +1 more
Small molecule targets P2RX3 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Lyfnua | — | 2023-09-15 | europa.eu ↗ |
Trials 27 · a red edge is where a trial was stopped
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 30 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Gefapixant | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02397460 ↗26 |
| Known as | AF-219 | “The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)” NCT01569438 ↗ |
| Known as | AF-219 CITRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Known as | Gefapixant Citrate | “Drug: Gefapixant Citrate” NCT06542484 ↗ |
| Known as | Lyfnua | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Known as | MK-7264 | “The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)” NCT01569438 ↗ |
| Known as | MK-7264 CITRATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Known as | R-1646 | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Known as | RG-1646 | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Known as | RO-4926219 | ChEMBL registry synonym — accepted as the source's own label CHEMBL3716057 ↗ |
| Action | Inhibit | “Gefapixant is a P2X3-receptor antagonist” PMID 35510785 ↗ May 2022 |
| Modality | Small molecule | — CHEMBL3716057 ↗ |
| Route | Oral | “orally with food for 4 weeks” NCT01569438 ↗ |
| Target | P2RX3 | “a P2X3 antagonist” PMID 31023843 ↗ Jul 2019 |