Drugs / Liatermin
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT00115427 | Mar 2003 → ? | Parkinson disease | Amgen | Completed | No outcome recorded |
| Phase 1 | NCT00006488 | — | Parkinson disease | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00111982 | Dec 2003 → Nov 2005 | Parkinson disease | Amgen | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00005903 | Jun 2000 → May 2005 | progressive supranuclear palsy | National Institute of Neurological Disorders and Stroke (NINDS) | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Liatermin | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00111982 ↗ |
| Known as | GDNF | “Recombinant-methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF or GDNF) is a neurotrophic factor that promotes survival of dopaminergic neurons.” NCT00006488 ↗ |
| Known as | Gdnf liatermin | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108380 ↗ |
| Known as | Liatermina | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108380 ↗ |
| Known as | Liatermine | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108380 ↗ |
| Known as | r-metHuGDNF | “The safety and initial efficacy of the unilateral intralenticular infusion of recombinant-methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) will be...” NCT00005903 ↗3“Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have...” NCT00111982 ↗ “Recombinant-methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF or GDNF) is a neurotrophic factor that promotes survival of dopaminergic neurons.” NCT00006488 ↗ “Liatermin (r-metHuGDNF) Administered by Bilateral Intraputaminal (IPu) Infusion” NCT00115427 ↗ |
| Action | Activate | “GDNF family receptor alpha-1 agonist” CHEMBL2108380 ↗ |
| Modality | Protein / enzyme biologic | “recombinant-methionyl human glial cell line-derived neurotrophic factor” NCT00005903 ↗ |
| Route | Other | “unilateral intralenticular infusion” NCT00005903 ↗ |
| Target | GFRA1 | “GDNF family receptor alpha-1 agonist” CHEMBL2108380 ↗ |