Drugs / SHR-1703
last change Jul 2026 re-read 2 minutes ago

SHR-1703

Monoclonal antibody targets IL5 via inhibition

Developed for
asthma · eosinophilic granulomatosis with polyangiitis · T2-high asthma
Investigated by
Guangdong Hengrui Pharmaceutical Co., Ltd · Jiangsu HengRui Medicine Co., Ltd. · Atridia Pty Ltd.

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT07701239 Jul 2026 → Apr 2027 expected asthma Guangdong Hengrui Pharmaceutical Co., Ltd Not yet recruiting No outcome recorded
Phase 1 NCT05042401 Oct 2021 → Jun 2023 asthma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1 NCT04855591 Jun → Sep 2021 asthma Atridia Pty Ltd. Terminated No outcome recorded
Phase 1 NCT04480762 Aug 2020 → Sep 2021 asthma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06441812 Jul 2024 → Sep 2028 expected T2-high asthma Guangdong Hengrui Pharmaceutical Co., Ltd Recruiting No outcome recorded
Phase 2 NCT05522439 Dec 2022 → Sep 2024 asthma Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT05979051 Nov 2023 → Dec 2028 expected eosinophilic granulomatosis with polyangiitis Guangdong Hengrui Pharmaceutical Co., Ltd Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06653322 Nov 2024 → Sep 2027 expected asthma Guangdong Hengrui Pharmaceutical Co., Ltd Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as SHR-1703 “A Multi-centered,Randomized,Double-blind,Placebo-controlled Study to Evaluate the Efficacy and Safety of SHR-1703 in Eosinophilic Asthma” NCT06653322
7

NCT07701239

NCT05979051

NCT05522439

NCT05042401

NCT06441812

NCT04480762

NCT04855591

Action Inhibit “an innovative long-acting anti-interleukin-5 monoclonal antibody” PMID 38805242 Jun 2024
Modality Monoclonal antibody “SHR-1703 is a novel humanized IgG1 monoclonal antibodyPMID 38805242 Jun 2024
Route Subcutaneous “administered subcutaneously” NCT04480762
Target IL5 “SHR-1703 is a novel humanized IgG1 monoclonal antibody with high IL-5 affinity” PMID 38805242 Jun 2024