Drugs / Elasomeran
last change Aug 2026 re-read 2 minutes ago

Elasomeran

Messenger RNA (mRNA)

Developed for
COVID-19 · disease related to solid organ transplantation · cancer · Orthocoronavirinae infectious disease · pneumonia · immunodeficiency disease
Investigated by
ModernaTX, Inc. · National Institute of Allergy and Infectious Diseases (NIAID) · Assistance Publique - Hôpitaux de Paris · Biomedical Advanced Research and Development Authority · Leiden University Medical Center · Merck Sharp & Dohme LLC
+82 more · Rho Federal Systems Division, Inc. · University Medical Center Groningen · Academic Medical Center - University of Amsterdam · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Autoimmunity Centers of Excellence · Beijing 302 Hospital · Beijing Institute of Biological Products Co Ltd. · BioNTech SE · CHU de Quebec-Universite Laval · COVID-19 Prevention Network · COVIREIVAC · Cardiothoracic Surgical Trials Network · Center for Disease Control and Prevention, Fujian · Chang Gung Memorial Hospital · China National Biotec Group Company Limited · Coalition for Epidemic Preparedness Innovations · DHR Health Institute for Research and Development · Erasmus Medical Center · French National Institute of Health and Medical Research · GeoVax, Inc. · GlaxoSmithKline · Guizhou Center for Disease Control and Prevention · Hunan Provincial Center for Disease Control and Prevention · Immune Tolerance Network (ITN) · Indonesia University · International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) · Johns Hopkins University · Jomo Kenyatta University of Agriculture and Technology · Jules Bordet Institute · Kirby Institute · Maria Joyera Rodríguez · McGill University Health Centre/Research Institute of the McGill University Health Centre · McMaster University · Medical Research Council · Medical Research Council, South Africa · Medigen Vaccine Biologics Corp. · Ministere de la Sante et des Services Sociaux · Ministerio de Salud de Ciudad Autónoma de Buenos Aires · Monash University · MonitorCRO · Murdoch Childrens Research Institute · NYU Langone Health · National Cancer Institute (NCI) · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Health Research and Development, Ministry of Health Republic of Indonesia · National Taiwan University Hospital · Novartis Pharmaceuticals · Osman ERGANIS, PhD, Prof · PPD Development, LP · Padjadjaran University · Pfizer · Prevention and Early Treatment of Acute Lung Injury · Providence Healthcare · Queen Mary University of London · Regeneron Pharmaceuticals · Roche Pharma AG · Scarborough General Hospital · Shanxi Provincial People's Hospital · Sheba Medical Center · Sinovac Biotech Co., Ltd · Sunnybrook Health Sciences Centre · Swiss Federal Institute of Technology · Takeda · The Peter Doherty Institute for Infection and Immunity · The Scientific and Technological Research Council of Turkey · Tor Biering-Sørensen · US Department of Veterans Affairs · Unity Health Toronto · University Health Network, Toronto · University of Alberta · University of Antwerp · University of Arizona · University of California, Los Angeles · University of Copenhagen · all 88 on the full record

Trials 59 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT05397223 May 2022 → Feb 2026 COVID-19, cytomegalovirus infection, influenza, respiratory syncytial virus infectious disease ModernaTX, Inc. Completed No outcome recorded
Phase 1 NCT04889274 May 2021 → Apr 2026 overdue cardiovascular disorder Queen Mary University of London Active not recruiting No outcome recorded
Phase 1 NCT04866069 Apr → Sep 2021 COVID-19 Osman ERGANIS, PhD, Prof Terminated No outcome recorded
Phase 1 NCT04785144 Mar 2021 → Jul 2022 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT04813796 Mar 2021 → Jul 2023 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 1 NCT04283461 Mar 2020 → Apr 2022 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT06683352 Nov 2024 → Jul 2025 COVID-19, influenza BioNTech SE Completed No outcome recorded
Phase 1/2 NCT05375838 May → Dec 2022 COVID-19, influenza ModernaTX, Inc. Completed No outcome recorded
Phase 1/2 NCT05280158 Mar 2022 → Feb 2023 Orthocoronavirinae infectious disease University of California, Los Angeles Terminated No outcome recorded
Phase 1/2 NCT05132855 Nov 2021 → Apr 2023 COVID-19 Chang Gung Memorial Hospital Unknown No outcome recorded
Phase 1/2 NCT04889209 May 2021 → Jun 2023 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/2 NCT04677660 Jan 2021 → Feb 2022 COVID-19 Takeda Completed No outcome recorded
Phase 213 trials
Phase 2 NCT05315362 May → Sep 2022 COVID-19 Leiden University Medical Center Unknown No outcome recorded
Phase 2 NCT05289037 Mar 2022 → Nov 2023 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT05077254 Dec 2021 → Feb 2024 disease related to solid organ transplantation National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT04977024 Sep 2021 → Dec 2026 expected COVID-19, leukemia, plasma cell myeloma GeoVax, Inc. Active not recruiting No outcome recorded
Phase 2 NCT04930770 Sep → Dec 2021 COVID-19 Maria Joyera Rodríguez Withdrawn No outcome recorded
Phase 2 NCT05000216 Aug 2021 → Jun 2023 juvenile dermatomyositis, juvenile idiopathic arthritis, pediatric multiple sclerosis, pediatric systemic lupus erythematosus +3 National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 2 NCT04969263 Aug 2021 → Nov 2022 disease related to solid organ transplantation National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT05027672 Jul → Aug 2021 Ministerio de Salud de Ciudad Autónoma de Buenos Aires Unknown No outcome recorded
Phase 2 NCT04852978 Apr 2021 → Nov 2022 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 2 NCT04847050 Apr 2021 → May 2023 leukemia, plasma cell myeloma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2/36 trials
Phase 2/3 NCT05168813 Dec 2021 → Apr 2024 COVID-19, HIV infectious disease COVID-19 Prevention Network Completed No outcome recorded
Phase 2/3 NCT05022329 Sep 2021 → May 2022 COVID-19, chronic kidney disease Sunnybrook Health Sciences Centre Terminated No outcome recorded
Phase 2/3 NCT05279365 Jul 2021 → Aug 2022 COVID-19 DHR Health Institute for Research and Development Unknown No outcome recorded
Phase 2/3 NCT04927065 May 2021 → Nov 2023 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 2/3 NCT04796896 Mar 2021 → Mar 2024 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 2/3 NCT04649151 Dec 2020 → Jun 2024 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 311 trials
Phase 3 NCT05387317 Apr 2024 → Jan 2025 COVID-19 Murdoch Childrens Research Institute Withdrawn No outcome recorded
Phase 3 NCT05556720 Dec 2022 → Jun 2026 overdue B-cell chronic lymphocytic leukemia, HIV infectious disease, disease related to solid organ transplantation, plasma cell myeloma Monash University Active not recruiting No outcome recorded
Phase 3 NCT05119855 Mar 2022 → Dec 2023 COVID-19, human papilloma virus infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT05158140 Jan 2022 → Feb 2023 pneumococcal infection Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT05230953 Jan 2022 → Jul 2024 COVID-19 Sheba Medical Center Unknown No outcome recorded
Phase 3 NCT05047770 Oct 2021 → Aug 2022 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT05028257 Sep 2021 → May 2023 anaphylaxis Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT04860297 Apr 2021 → May 2023 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 3 NCT04811664 Mar → Dec 2021 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT04806113 Mar → Jun 2021 COVID-19, rheumatoid arthritis, systemic lupus erythematosus McGill University Health Centre/Research Institute of the McGill University Health Centre Completed No outcome recorded
Phase 412 trials
Phase 4 NCT07279766 Dec 2025 → Aug 2026 overdue COVID-19 Tor Biering-Sørensen Active not recruiting No outcome recorded
Phase 4 NCT07266558 Nov 2025 → Jun 2027 expected COVID-19 ModernaTX, Inc. Active not recruiting No outcome recorded
Phase 4 NCT05075538 Dec 2021 → Jan 2024 cancer Jules Bordet Institute Terminated No outcome recorded
Phase 4 NCT05107557 Nov → Dec 2021 COVID-19 Sinovac Biotech Co., Ltd Completed No outcome recorded
Phase 4 NCT05104333 Nov 2021 → Nov 2022 pneumonia China National Biotec Group Company Limited Unknown No outcome recorded
Phase 4 NCT05079633 Sep → Oct 2021 National Taiwan University Hospital Completed No outcome recorded
Phase 4 NCT04969250 Aug 2021 → Dec 2022 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 4 NCT05012800 Jul 2021 → Aug 2022 Beijing 302 Hospital Unknown No outcome recorded
Phase 4 NCT04952402 Jul 2021 → Feb 2022 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 4 NCT06189040 May → Nov 2021 COVID-19 University of Antwerp Completed No outcome recorded
Phase not applicable5 trials
NCT06116669 Nov 2023 → Dec 2024 iron deficiency anemia Swiss Federal Institute of Technology Unknown No outcome recorded
NCT04927936 Jun 2021 → Sep 2022 COVID-19 Erasmus Medical Center Unknown No outcome recorded
NCT04900467 May → Jul 2021 Assistance Publique - Hôpitaux de Paris Unknown No outcome recorded
NCT05019456 Mar 2021 → Dec 2025 overdue COVID-19, influenza University of Arizona Active not recruiting No outcome recorded
NCT04715438 Jan → Jun 2021 cancer University Medical Center Groningen Unknown No outcome recorded
Also used as a comparator or background therapy in 25 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05081271 Comparator Oct 2021 → May 2022 multiple sclerosis Griffin Hospital Terminated No outcome recorded
Phase 28 trials
Phase 2 NCT05383560 Comparator Sep 2022 → Jan 2024 COVID-19 Sheba Medical Center Completed No outcome recorded
Phase 2 NCT05345873 Comparator Jul → Oct 2022 COVID-19 Sinocelltech Ltd. Unknown No outcome recorded
Phase 2 NCT05197153 Comparator Jan → Jun 2022 Medigen Vaccine Biologics Corp. Completed No outcome recorded
Phase 2 NCT05137236 Comparator Dec 2021 → Mar 2023 Orthocoronavirinae infectious disease ModernaTX, Inc. Completed No outcome recorded
Phase 2 NCT05160766 Comparator Nov 2021 → Oct 2022 Oliver Cornely, MD Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT05236491 Comparator Mar 2022 → Jun 2023 overlapping connective tissue disease, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis +2 Paul R Fortin Unknown No outcome recorded
Phase 2/3 NCT05249829 Comparator Feb 2022 → Jun 2023 COVID-19 ModernaTX, Inc. Completed No outcome recorded
Phase 39 trials
Phase 3 NCT06694389 Comparator Nov 2024 → Nov 2025 COVID-19, influenza ModernaTX, Inc. Completed No outcome recorded
Phase 3 NCT06354998 Comparator Apr → May 2024 Orthocoronavirinae infectious disease ModernaTX, Inc. Completed No outcome recorded
Phase 3 NCT06178991 Comparator Dec 2023 → Nov 2024 COVID-19, influenza BioNTech SE Completed No outcome recorded
Phase 3 NCT06097273 Comparator Oct 2023 → May 2024 Orthocoronavirinae infectious disease, influenza ModernaTX, Inc. Completed No outcome recorded
Phase 3 NCT05415267 Comparator Jul 2023 → Dec 2026 expected COVID-19 Kirby Institute Recruiting No outcome recorded
Phase 44 trials
Phase 4 NCT06441955 Comparator Mar 2024 → Sep 2030 expected long COVID-19 Well- Konnect Healthcare Services and Research Firm Recruiting No outcome recorded
Phase 4 NCT05030974 Comparator Oct 2021 → Mar 2022 COVID-19, kidney disorder University Medical Center Groningen Completed No outcome recorded
Phase 4 NCT04885907 Comparator May → Jul 2021 COVID-19, immunodeficiency disease University Health Network, Toronto Completed No outcome recorded
Phase 4 NCT04760132 Comparator Feb 2021 → Dec 2023 Orthocoronavirinae infectious disease Jens D Lundgren, MD Completed No outcome recorded
Phase not applicable1 trial
NCT05074368 Comparator Jul 2021 → Apr 2022 National Taiwan University Hospital Completed No outcome recorded

Press releases naming this drug 310 releases

DateIssuerRelease
2026-07-29 Pfizer European Commission Authorizes Pfizer and BioNTech XFG-adapted COVID-19 Vaccine in the European Union pfizer.com
2026-07-29 BioNTech SE European Commission Authorizes Pfizer and BioNTech XFG-adapted COVID-19 Vaccine in the European Union biontech.com
2026-04-18 Sanofi Press Release: ESCMID: Sanofi's Nuvaxovid COVID-19 vaccine showed better tolerability than mNEXSPIKE in head-to-head study sanofi.com
2025-09-08 Pfizer Pfizer and BioNTech Announce Topline Data Demonstrating Robust Immune Response With Their LP.8.1-Adapted COVID-19 Vaccine 2025-2026 Formula pfizer.com
2025-09-08 BioNTech SE Pfizer and BioNTech Announce Topline Data Demonstrating Robust Immune Response with their LP.8.1-adapted COVID-19 Vaccine 2025-2026 Formula biontech.com
2025-07-25 Pfizer Pfizer and BioNTech Receive Positive CHMP Opinion for LP.8.1-adapted COVID-19 Vaccine in the European Union pfizer.com
2025-07-25 BioNTech SE Pfizer and BioNTech Receive Positive CHMP Opinion for LP.8.1-Adapted COVID-19 Vaccine in the European Union biontech.com
2025-05-28 BioNTech SE Pfizer and BioNTech Submit EMA Application for COVID-19 Vaccine Targeting LP.8.1 for 2025-2026 Season biontech.com
2025-01-06 ModernaTX, Inc. Moderna – 2024 Shareholder Letter from CEO Stéphane Bancel modernatx.com
2024-12-20 ModernaTX, Inc. Moderna – The Hidden Cost of COVID: Long COVID's Impact on the Workforce modernatx.com
2024-12-12 ModernaTX, Inc. Moderna’s Commitment to Patient Access in the United States modernatx.com
2024-09-20 Pfizer Pfizer and BioNTech Receive Positive CHMP Opinion for Omicron KP.2-adapted COVID-19 Vaccine in the European Union pfizer.com
Show all 310 releases opens the full record — a long page

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 91 sources stand behind the page.

FieldValueCited text
Known as Elasomeran ClinicalTrials.gov intervention name — accepted as the source's own label NCT05543356
1

NCT05228730

Known as Comirnaty Pfizer COVID19 vaccine Comirnaty Pfizer COVID19 vaccineNCT05028257
Known as COVID-19 vaccine “The COVID-19 vaccine was manufactured by Sinovac Research” NCT05107557
9

NCT06683352

NCT06178991

NCT05104333

NCT05012800

NCT06116669

NCT04977024

NCT04889274

NCT05019456

NCT05415267

Known as COVID-19 vaccine (Vero cell), Inactivated “This study is a randomized and controlled Phase IV clinical trial of the COVID-19 vaccine (Vero cell), Inactivated manufactured by Sinovac Research” NCT05107557
Known as COVID-19 Vaccine Moderna “Study About the Response to the Administration of a Third Dose of mRNA-1273 Vaccine (COVID-19 Vaccine Moderna)” NCT04930770
2

“mRNA-1273, COVID-19 Vaccine Moderna, mARN vaccine, administrated by intramuscular” NCT04900467

NCT04760132

Known as CX-024414 ChEMBL registry synonym — accepted as the source's own label CHEMBL4650491
Known as M-1273 ChEMBL registry synonym — accepted as the source's own label CHEMBL4650491
Known as messenger RNA-1273 “SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine” NCT05074368
Known as Moderna “Participants ( n =273) with CKD not on dialysis or receiving dialysis were randomized 1:1 to third dose 30- µ g BNT162b2 (Pfizer-BioNTech) or 100- µ g mRNA-1273 (Moderna).” PMID 37847518 Oct 2023
3

“SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine” NCT05074368

NCT05387317

NCT05279365

Known as Moderna (mRNA-1273 or Spikevax) Moderna (mRNA-1273 or Spikevax)NCT04988048
Known as Moderna Bivalent mRNA vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT05556720
Known as Moderna COVID-19 vaccine Moderna COVID-19 Vaccine, mRNA-1273 (100 μg)” NCT04805125
8

“mRNA-1273 (Moderna COVID-19 vaccine) 50 ug” NCT05280158

Moderna COVID-19 vaccine (mRNA 1273)” NCT05079633

“mRNA-1273 (Moderna COVID-19 vaccine)” NCT07279766

“Moderna COVID19 vaccine” NCT05028257

NCT04761822

NCT04811664

NCT06441955

NCT04806113

Known as Moderna COVID-19 Vaccine 2023-2024 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05077254
Known as Moderna covid-19 vaccine rna ChEMBL registry synonym — accepted as the source's own label CHEMBL4650491
Known as Moderna mRNA-1273 “For dose 1 and 2, the currently available mRNA vaccines (Pfizer-BioNTech BNT162b2 and Moderna mRNA-1273) are two dose vaccines which were studied in schedules of either 0 and...” NCT04894435
1

NCT05000216

Known as Moderna mRNA-1273 COVID-19 vaccine “Study-provided Moderna mRNA-1273 COVID-19 vaccineNCT04952402
Known as mRNA 1273 “Participants ( n =273) with CKD not on dialysis or receiving dialysis were randomized 1:1 to third dose 30- µ g BNT162b2 (Pfizer-BioNTech) or 100- µ g mRNA-1273 (Moderna).” PMID 37847518 Oct 2023
56

“We recruited adult volunteers for homologous or heterologous prime-boost vaccinations with adenoviral (ChAdOx1, AstraZeneca) and/or mRNA (mRNA-1273, Moderna) vaccines.” PMID 35305895 Mar 2022

“The mRNA vaccine, mRNA-1273/TAK-919, encodes the prefusion-stabilised spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).” PMID 35177302 Feb 2022

“mRNA-1273 or Spikevax Moderna Switzerland GmbH and the National Institute of Allergy and Infectious Diseases (NIAID) of the United States.” NCT04988048

“The participants were assigned to receive no booster, an Ad26.COV2.S booster, an mRNA-1273 booster, or a BNT162b2 booster.” PMID 35045226 Jan 2022

“mRNA-1273 Injection (Drug Product) is an lipid nanoparticles (LNPs) dispersion containing a single mRNA sequence” NCT04847050

“Study About the Response to the Administration of a Third Dose of mRNA-1273 Vaccine (COVID-19 Vaccine Moderna)” NCT04930770

“This means Ad26.COV2.S if they originally received BNT162b2 or mRNA-1273 or vice versa” NCT05081271

“mRNA-1273, COVID-19 Vaccine Moderna, mARN vaccine, administrated by intramuscular” NCT04900467

“the vaccine produced by Moderna (mRNA-1273)” NCT05027672

“with mRNA-1273 (Moderna COVID-19) vaccine” NCT04818736

“COVID-19 (all ages: mRNA-1273) vaccines.” PMID 40332892 Jun 2025

“Moderna COVID-19 vaccine (mRNA 1273)” NCT05079633

“mRNA vaccine mRNA-1273” PMID 37321955 Jun 2023

“Spikevax (mRNA-1273)” NCT05160766

NCT05132855

NCT05030974

NCT04969250

NCT04785144

NCT05324319

NCT04748471

NCT04860297

NCT04885907

NCT04852978

NCT04930770

NCT04470427

NCT04405076

NCT05249829

NCT05197153

NCT05383560

NCT05158140

NCT07266558

NCT04805125

NCT05168813

NCT04952402

NCT05315362

NCT07279766

NCT04649151

NCT05047770

NCT05119855

NCT06189040

NCT05345873

NCT04283461

NCT04894435

NCT04889209

NCT04796896

NCT04813796

NCT04969263

NCT04715438

NCT04792567

NCT05397223

NCT05289037

NCT05137236

NCT05375838

NCT05280158

NCT05230953

NCT04927065

Known as mRNA-1273 SARS-CoV-2 Vaccine “Participants will be blinded and receive two doses (0.20 mg/mL each) of mRNA-1273 SARS-CoV-2 vaccine via intramuscular injection in the deltoid muscle 28 days apart.” NCT04894435
1

mRNA-1273 SARS-CoV-2 VaccineNCT05022329

Known as SARS-CoV-2 vaccine ClinicalTrials.gov intervention name — accepted as the source's own label NCT04866069
1

NCT06694389

Known as Spikevax “single fractional dose of 20µg mRNA-1273 LNP vaccine (Spikevax, Moderna) more than 3 months after primary vaccination with Comirnaty (Pfizer) vaccine and/or after having...” NCT05315362
7

“For the Moderna SPIKEVAX Bivalent Original/Omicron BA.4/5: participants will receive one (1) intramuscular injection of 0.5 mL (50 mcg).” NCT05236491

“For this arm, the current variant formulation of Spikevax (mRNA-1273) vaccine will be used.” NCT07279766

“following mRNA-1273 (Spikevax™) vaccination” PMID 36376733 Nov 2022

NCT05075538

NCT05160766

NCT05048940

NCT06354998

Known as Spikevax (previously covid-19 vaccine moderna) ChEMBL registry synonym — accepted as the source's own label CHEMBL4650491
Known as SPIKEVAX Bivalent Original/Omicron BA.4/5 “For the Moderna SPIKEVAX Bivalent Original/Omicron BA.4/5: participants will receive one (1) intramuscular injection of 0.5 mL (50 mcg).” NCT05236491
Known as Spikevax Moderna vaccine “Spikevax (Moderna) vaccine” NCT05048940
Known as Spikevax mrna ChEMBL registry synonym — accepted as the source's own label CHEMBL4650491
Known as TAK-919 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04677660