Drugs / ANPOCOGIN
ANPOCOGIN
also known as
AB-201 · rNAPc2 · Recombinant nematode anticoagulant protein c2 · Anpocogina · Anpocogine · Nematode anticoagulant protein c2 · Recombinant NAPc2 · Recombinant nematode anticoagulant protein c2 (rnapc2)
Cell therapy targets TF via inhibition
Trials 6 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT07333820 | Feb → Jul 2026 overdue | gastric cancer | Yonsei University | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT06341647 | Oct 2024 → Apr 2027 | breast cancer, gastric cancer, gastroesophageal junction adenocarcinoma | GC Cell Corporation | Withdrawn | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT05678205 | Aug 2023 → Apr 2027 | breast cancer, gastric cancer, gastroesophageal junction adenocarcinoma | Artiva Biotherapeutics, Inc. | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT00443573 | Dec 2006 → Aug 2007 | colon carcinoma | ARCA Biopharma, Inc. | Suspended | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00116012 | Jun 2005 → ? | coronary artery disorder | ARCA Biopharma, Inc. | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT04655586 | Dec 2020 → Dec 2021 | COVID-19 | ARCA Biopharma, Inc. | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | ANPOCOGIN | ChEMBL registry synonym — accepted as the source's own label CHEMBL4298082 ↗ |
| Known as | AB-201 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07333820 ↗ |
| Known as | Anpocogina | ChEMBL registry synonym — accepted as the source's own label CHEMBL4298082 ↗ |
| Known as | Anpocogine | ChEMBL registry synonym — accepted as the source's own label CHEMBL4298082 ↗ |
| Known as | Nematode anticoagulant protein c2 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4298082 ↗ |
| Known as | Recombinant NAPc2 | “Recombinant NAPc2 is a potent inhibitor of the tissue factor/factor VIIa complex that has the potential to reduce ischemic complications mediated by thrombin generation.” PMID 17599602 ↗ Jun 2007 |
| Known as | Recombinant nematode anticoagulant protein c2 | “OBJECTIVES: We sought to evaluate the safety and efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients with non-ST-segment elevation acute coronary...” PMID 17599602 ↗ Jun 20071“recombinant nematode anticoagulant protein c2 (rNAPc2)” NCT00443573 ↗ |
| Known as | Recombinant nematode anticoagulant protein c2 (rnapc2) | ChEMBL registry synonym — accepted as the source's own label CHEMBL4298082 ↗ |
| Known as | rNAPc2 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04655586 ↗ |
| Action | Inhibit | “Recombinant NAPc2 is a potent inhibitor of the tissue factor/factor VIIa complex” PMID 17599602 ↗ Jun 2007 |
| Modality | Protein / enzyme biologic | “Recombinant nematode anticoagulant protein c2 (rNAPc2)” NCT00116012 ↗ |
| Route | Intravenous | “double-blinded intravenous rNAPc2 or placebo every 48 h” PMID 17599602 ↗ Jun 2007 |
| Target | TF | “novel TF inhibitor rNAPc2” PMID 37381988 ↗ Jun 2023 |