Drugs / BI 1358894
last change Feb 2024 re-read 2 minutes ago

BI 1358894

Small molecule targets TRPC4 via inhibition

Developed for
major depressive disorder · borderline personality disorder · post-traumatic stress disorder
Investigated by
Boehringer Ingelheim

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 113 trials
Phase 1 NCT05934942 Sep 2023 → Feb 2024 Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT05155306 Jan → May 2022 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT04899674 Jun → Sep 2021 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT04567316 Oct 2020 → Jan 2021 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT04426851 Jul → Oct 2020 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT04099732 Oct → Dec 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03904576 Apr → Aug 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03892616 Apr → Jul 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03875001 Mar → Jul 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03843151 Mar → Jun 2019 Boehringer Ingelheim Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05103657 Dec 2021 → Oct 2023 post-traumatic stress disorder Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT04521478 Nov 2020 → Jan 2024 major depressive disorder Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT04566601 Nov 2020 → Dec 2022 borderline personality disorder Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT04423757 Jun 2020 → Apr 2022 major depressive disorder Boehringer Ingelheim Terminated No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as BI 1358894 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05934942
16

NCT03754959

NCT03875001

NCT05155306

NCT04567316

NCT04521478

NCT04566601

NCT04899674

NCT03904576

NCT04426851

NCT04099732

NCT03210272

NCT05103657

NCT04423757

NCT03854578

NCT03892616

NCT03843151

Action Inhibit “BI 1358894, a small-molecule inhibitor of TRPC ion channels, is currently being developed for the treatment of MDD.” PMID 38019355 Nov 2023
Modality Small molecule “BI 1358894, a small-molecule inhibitor of TRPC ion channels, is currently being developed for the treatment of MDD.” PMID 38019355 Nov 2023
Route Oral oral administration of single rising doses” NCT03210272
Target TRPC4 “TRPC ion channel members 4 and 5 (TRPC4/5)” PMID 38019356 Nov 2023