Drugs / Fulacimstat
last change Oct 2019 re-read 3 minutes ago

Fulacimstat

also known as BAY1142524

Small molecule targets CMA1 via inhibition

Developed for
diabetic kidney disease · heart failure · myocardial infarction
Investigated by
Bayer

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03402438 Feb → Dec 2018 — Bayer Completed No outcome recorded
Phase 23 trials · 1 missed
Phase 2 NCT03412006 Feb 2018 → Oct 2019 diabetic kidney disease Bayer Completed No outcome recorded
Phase 2 NCT02976467 Dec 2016 → Jul 2018 myocardial infarction Bayer Completed Missed primary
Phase 2 NCT02452515 Jul 2015 → Jan 2016 heart failure Bayer Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Fulacimstat ClinicalTrials.gov intervention name — accepted as the source's own label NCT02976467 ↗
2

NCT03402438 ↗

NCT03412006 ↗

Known as BAY1142524 “Fulacimstat (BAY1142524)” NCT03402438 ↗
3

“Fulacimstat (BAY1142524)” NCT02976467 ↗

“Fulacimstat (BAY1142524)” NCT03412006 ↗

NCT02452515 ↗

Action Inhibit “the chymase inhibitor BAY1142524” NCT02452515 ↗
1

“Chymase inhibitor” CHEMBL4297596 ↗

Modality Small molecule — CHEMBL4297596 ↗
Route Oral “14 Day Oral Treatment With Different Doses of the Chymase Inhibitor BAY1142524” NCT02452515 ↗
Target CMA1 “Chymase inhibitor” CHEMBL4297596 ↗