Drugs / Zucapsaicin
last change Feb 2026 re-read 3 minutes ago

Zucapsaicin

Small molecule targets TRPV1 via activation

Developed for
cluster headache syndrome · dry eye syndrome · osteoarthritis, knee · postherpetic neuralgia
Investigated by
Winston Laboratories

Trials 4

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT02116244 May 2014 → Sep 2015 dry eye syndrome Winston Laboratories Completed No outcome recorded
Phase 2 NCT00845923 Mar → Sep 2009 postherpetic neuralgia Winston Laboratories Completed No outcome recorded
Phase 32 trials
Phase 3 NCT00077935 Nov 2003 → Jul 2005 osteoarthritis, knee Winston Laboratories Completed No outcome recorded
Phase 3 NCT00033839 Jan 2002 → Jul 2003 cluster headache syndrome Winston Laboratories Completed No outcome recorded
Comparator or background therapy6 trials
Phase 1 NCT00802217 Comparator Nov 2008 → Jun 2009 — Winston Laboratories Terminated No outcome recorded
Phase 1 NCT00758433 Comparator Sep → Dec 2008 — Winston Laboratories Completed No outcome recorded
Phase 2 NCT01886313 Comparator Mar 2014 → Mar 2015 postherpetic neuralgia Winston Laboratories Terminated No outcome recorded
Phase 3 NCT01341548 Comparator Nov 2023 → Nov 2025 cluster headache syndrome Winston Laboratories Unknown No outcome recorded
Phase 3 NCT00069082 Comparator Aug 2003 → Jan 2004 cluster headache syndrome Winston Laboratories Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 11 sources stand behind the page.

FieldValueCited text
Known as Zucapsaicin “A DOUBLE BLIND, RANDOMIZED, VEHICLE-CONTROLLED, PARALLEL-GROUP EVALUATION OF CIVAMIDE (ZUCAPSAICIN) 0.01% AND VEHICLE NASAL SPRAYS IN THE TREATMENT OF POSTHERPETIC NEURALGIA OF...” NCT01886313 ↗
3

“A Phase III, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Evaluation of Civamide (Zucapsaicin) Nasal Solution in the Treatment of Episodic Cluster Headache” NCT00069082 ↗

“Civamide (Zucapsaicin)” NCT00033839 ↗

“Drug: Zucapsaicin” NCT00758433 ↗

Known as Cis-capsaicin ChEMBL registry synonym — accepted as the source's own label CHEMBL313971 ↗
Known as Civamide ClinicalTrials.gov intervention name — accepted as the source's own label NCT00995306 ↗
8

NCT00802217 ↗

NCT00077935 ↗

NCT01341548 ↗

NCT02116244 ↗

NCT01886313 ↗

NCT00845923 ↗

NCT00033839 ↗

NCT00069082 ↗

Known as Zucapsaicina ChEMBL registry synonym — accepted as the source's own label CHEMBL313971 ↗
Known as Zucapsaicine ChEMBL registry synonym — accepted as the source's own label CHEMBL313971 ↗
Action Activate “Vanilloid receptor agonist” CHEMBL313971 ↗
Modality Small molecule — CHEMBL313971 ↗
Route Intranasal “Intranasal Civamide (Zucapsaicin)” NCT00033839 ↗
Target TRPV1 “Vanilloid receptor agonist” CHEMBL313971 ↗