Drugs / Inclacumab
last change Nov 2025 re-read 3 minutes ago

Inclacumab

also known as RO4905417 · LC-1004-002 · RG1512

Monoclonal antibody targets SELP via inhibition

Developed for
sickle cell disease · arterial occlusion · myocardial infarction · peripheral arterial disease
Investigated by
Hoffmann-La Roche · Pfizer

Trials 7

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01815827 Jun 2013 → Feb 2014 — Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT00760565 Sep 2008 → Jun 2011 peripheral arterial disease Hoffmann-La Roche Completed No outcome recorded
Phase 22 trials · 1 missed
Phase 2 NCT01327183 May 2011 → Oct 2012 myocardial infarction Hoffmann-La Roche Completed Missed primary
Phase 2 NCT01245634 Dec 2010 → May 2013 arterial occlusion Hoffmann-La Roche Completed No outcome recorded
Phase 33 trials · 2 missed
Phase 3 NCT05348915 Mar 2022 → Nov 2025 sickle cell disease Pfizer Terminated No outcome recorded Stop: Business
Phase 3 NCT04927247 Dec 2021 → Nov 2023 sickle cell disease Pfizer Terminated Missed primary Stop: Enrollment
Phase 3 NCT04935879 Oct 2021 → Jun 2024 sickle cell disease Pfizer Completed Missed primary

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as Inclacumab ClinicalTrials.gov intervention name — accepted as the source's own label NCT04935879 ↗
3

NCT01815827 ↗

NCT05348915 ↗

NCT04927247 ↗

Known as LC-1004-002 ChEMBL registry synonym — accepted as the source's own label CHEMBL2109488 ↗
Known as RG1512 ChEMBL registry synonym — accepted as the source's own label CHEMBL2109488 ↗
Known as RO4905417 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00760565 ↗
2

NCT01245634 ↗

NCT01327183 ↗

Action Inhibit “P-Selectin Antagonist Inclacumab” PMID 26796402 ↗ Jan 2016
Modality Monoclonal antibody “Recombinant Human Monoclonal Antibody Against P-selectin” NCT01245634 ↗
Route Intravenous “Following Intravenous Infusion” NCT00760565 ↗
Target SELP “Recombinant Human Monoclonal Antibody Against P-selectin” NCT01245634 ↗