Drugs / cimlanod
last change Nov 2020 re-read 2 minutes ago

cimlanod

also known as BMS-986231 · CXL-1427

Other / unclassified

Developed for
heart failure · congestive heart failure · left ventricular failure
Investigated by
Bristol-Myers Squibb · Cardioxyl Pharmaceuticals, Inc

Trials 9 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT03515980 May 2018 → Aug 2019 congestive heart failure, liver failure Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03332186 Mar → Oct 2018 congestive heart failure, kidney failure Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03210909 Jun → Jul 2017 heart failure Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02932969 Oct 2016 → May 2017 heart failure Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02819271 Feb → Apr 2014 heart failure Bristol-Myers Squibb Completed No outcome recorded
Phase 24 trials
Phase 2 NCT03730961 Jan → Dec 2019 congestive heart failure Bristol-Myers Squibb Completed No outcome recorded
Phase 2 NCT03357731 Nov 2017 → May 2019 left ventricular failure Bristol-Myers Squibb Completed No outcome recorded
Phase 2 NCT03016325 Jan 2017 → Jun 2019 heart failure Bristol-Myers Squibb Completed No outcome recorded
Phase 2 NCT02157506 Jun 2014 → May 2015 heart failure Bristol-Myers Squibb Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT03891108 Comparator Feb → Jul 2019 heart failure Bristol-Myers Squibb Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as cimlanod “Bristol-Myers Squibb-986231 (cimlanod) is an HNO donor being developed for acute heart failure (AHF).” PMID 33248986 Nov 2020
Known as BMS-986231 BMS-986231 is an HNO donor being developed as a therapy for heart failure” PMID 31168885 Jun 2019
6

NCT03210909

NCT03891108

NCT03730961

NCT02932969

NCT03515980

NCT03332186

Known as CXL-1427 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02157506
1

NCT02819271

Modality Other / unclassified “BMS-986231 is an HNO donor” PMID 31168885 Jun 2019
Route Intravenous “continuous 6-hour IV infusions of CXL-1427” NCT02157506