Drugs / tanespimycin
last change Apr 2014 re-read 9 days ago

tanespimycin

Developed for
cancer of unknown primary site · mantle cell lymphoma · anaplastic large cell lymphoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · MALT lymphoma · nodal marginal zone B-cell lymphoma · adult T-cell leukemia/lymphoma · angioimmunoblastic T-cell lymphoma
+73 more · Burkitt lymphoma · Hodgkins lymphoma · large-cell immunoblastic lymphoma · mycosis fungoides and variants · splenic marginal zone lymphoma · diffuse large B-cell lymphoma · kidney cancer · leukemia · small intestine lymphoma · Waldenstrom macroglobulinemia · acute basophilic leukemia · acute erythroid leukemia · acute lymphoblastic leukemia · acute megakaryoblastic leukemia · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · adult acute monocytic leukemia · B-cell chronic lymphocytic leukemia · breast cancer · cancer · cutaneous melanoma · Ewing sarcoma/peripheral primitive neuroectodermal tumor · grade III lymphomatoid granulomatosis · intraocular lymphoma · lymphoma · osteosarcoma · acute myeloid leukemia · acute undifferentiated leukemia · AIDS-related primary central nervous system lymphoma · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · central nervous system non-hodgkin lymphoma · childhood acute lymphoblastic leukemia · childhood acute myeloid leukemia · chondrosarcoma · chronic myeloid leukemia · chronic myelomonocytic leukemia · colorectal cancer · desmoplastic small round cell tumor · extranodal nasal NK/T cell lymphoma · female breast carcinoma · gastric cancer · head and neck cancer · HIV-associated cancer · immunodeficiency-associated lymphoproliferative disease · leukemia, myeloid, accelerated-phase · lung cancer · medullary thyroid gland carcinoma · metastatic melanoma · myeloproliferative neoplasm · neuroblastoma · ovarian cancer · ovarian carcinoma · ovarian sarcoma · pancreatic adenocarcinoma · peritoneal carcinoma · plasma cell myeloma · post-transplant lymphoproliferative disease · prolymphocytic leukemia · prostate adenocarcinoma · prostate cancer · prostate carcinoma · refractory anemia with excess blasts in transformation · rhabdomyosarcoma · thyroid gland papillary carcinoma · urinary bladder cancer · uterine corpus sarcoma · von Hippel-Lindau disease
Investigated by
National Cancer Institute (NCI) · Bristol-Myers Squibb · Cancer Research UK · Memorial Sloan Kettering Cancer Center · Barbara Ann Karmanos Cancer Institute · Biogen
+3 more · Celgene Corporation · Mayo Clinic · National Institutes of Health Clinical Center (CC)

Trials 34

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 120 trials
Phase 1 NCT00820768 Apr 2012 → Apr 2013 cancer Celgene Corporation Withdrawn No outcome recorded
Phase 1 NCT00354185 May 2006 → Feb 2008 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, Waldenstrom macroglobulinemia +15 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00319930 May 2005 → May 2007 B-cell chronic lymphocytic leukemia Biogen Terminated No outcome recorded
Phase 1 NCT00119236 May 2005 → Oct 2008 cancer of unknown primary site National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00098488 Apr 2005 → Apr 2008 B-cell chronic lymphocytic leukemia, prolymphocytic leukemia National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00103272 Apr 2005 → Apr 2008 MALT lymphoma, Waldenstrom macroglobulinemia, acute basophilic leukemia, acute erythroid leukemia +20 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00121264 Mar 2005 → Jul 2010 — National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00096005 Nov 2004 → Mar 2010 Burkitt lymphoma, HIV-associated cancer, Hodgkins lymphoma, MALT lymphoma +11 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00098423 Nov 2004 → May 2009 acute basophilic leukemia, acute erythroid leukemia, acute lymphoblastic leukemia, acute megakaryoblastic leukemia +13 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00093821 Sep 2004 → Aug 2007 Ewing sarcoma/peripheral primitive neuroectodermal tumor, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia +4 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00773344 Dec 2005 → May 2009 breast cancer Bristol-Myers Squibb Completed No outcome recorded
Phase 212 trials
Phase 2 NCT00577889 Mar 2008 → Jan 2011 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00093496 Oct 2007 → Apr 2010 ovarian carcinoma, peritoneal carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00779428 Jul 2006 → Mar 2013 cancer Bristol-Myers Squibb Completed No outcome recorded
Phase 2 NCT00132015 May 2006 → Dec 2007 leukemia, lymphoma, myeloproliferative neoplasm, precancerous condition National Institutes of Health Clinical Center (CC) Completed No outcome recorded
Phase 2 NCT00096109 Sep 2005 → May 2012 female breast carcinoma National Cancer Institute (NCI) Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT00104897 Mar 2005 → Nov 2010 cutaneous melanoma Cancer Research UK Completed No outcome recorded
Phase 2 NCT00117988 Feb 2005 → Apr 2010 Hodgkins lymphoma, anaplastic large cell lymphoma, mantle cell lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00118092 Jan 2005 → May 2006 prostate adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00118248 Dec 2004 → Aug 2009 medullary thyroid gland carcinoma, thyroid gland papillary carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00093405 Aug 2004 → Nov 2005 kidney cancer Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00514371 Aug 2007 → Feb 2009 plasma cell myeloma Bristol-Myers Squibb Completed No outcome recorded
Comparator or background therapy1 trial
Phase 3 NCT00546780 Comparator Feb 2008 → Mar 2010 plasma cell myeloma Bristol-Myers Squibb Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 36 sources stand behind the page.

FieldValueCited text
Known as tanespimycin ClinicalTrials.gov intervention name — accepted as the source's own label NCT00514371 ↗
31

NCT00104897 ↗

NCT00117988 ↗

NCT00103272 ↗

NCT00132015 ↗

NCT00093405 ↗

NCT00577889 ↗

NCT00119236 ↗

NCT00354185 ↗

NCT00004065 ↗

NCT00118248 ↗

Show 21 more sources

Known as 17-(Allylamino)-17- Demethoxygeldanamycin “A Phase II Clinical Trial of 17-(Allylamino)-17- Demethoxygeldanamycin (17-AAG, NSC 330507 and EPL Diluent, NSC 704057) in Adults With Systemic Mastocytosis” NCT00132015 ↗
1

NCT00088374 ↗

Known as 17-AAG “A Phase II Clinical Trial of 17-(Allylamino)-17- Demethoxygeldanamycin (17-AAG, NSC 330507 and EPL Diluent, NSC 704057) in Adults With Systemic Mastocytosis” NCT00132015 ↗
3

“17-N-allylamino-17-demethoxygeldanamycin (17-AAG) in patients with refractory or advanced solid tumors or hematologic malignancies.” NCT00004065 ↗

“A Phase I of ABI-010 (Nab-17-AAG) and ABI-007 (Abraxane) Administered Weekly in Patients With Advanced Non-Hematologic Malignancies” NCT00820768 ↗

“CNF1010 (17-AAG)” NCT00319930 ↗

Known as 17-N-allylamino-17-demethoxy Geldanamycin “Determine the 1-year treatment failure rate in patients with inoperable locoregionally advanced or metastatic medullary or differentiated thyroid carcinoma treated with...” NCT00118248 ↗
3

“Phase II Trial of 17-N-allylamino-17-demethoxy Geldanamycin (17-AAG, NSC #330507) Diluted in EPL Diluent (NSC #704057) in Metastatic Melanoma Patients” NCT00087386 ↗

“17-N-Allylamino-17-Demethoxy Geldanamycin (17-AAG, NSC #330507) Daily X 5 in Patients With Advanced Cancer Therapeutic Protocol” NCT00004065 ↗

“Patients receive 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) IV over 2-6 hours” NCT00132015 ↗

Known as CNF1010 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00319930 ↗
Known as KOS-953 “This is a phase 3, open label trial for patients with multiple myeloma in first relapse. Trial will compare tanespimycin (KOS-953), in combination with a fixed dose of...” NCT00546780 ↗
1

“Study agent is tanespimycin (KOS-953), at three different dose levels in combination with a fixed dose of bortezomib.” NCT00514371 ↗

Known as NSC #330507 “A Phase II Clinical Trial of 17-(Allylamino)-17- Demethoxygeldanamycin (17-AAG, NSC 330507 and EPL Diluent, NSC 704057) in Adults With Systemic Mastocytosis” NCT00132015 ↗
2

“Phase II Trial of 17-N-allylamino-17-demethoxy Geldanamycin (17-AAG, NSC #330507) Diluted in EPL Diluent (NSC #704057) in Metastatic Melanoma Patients” NCT00087386 ↗

“17-N-Allylamino-17-Demethoxy Geldanamycin (17-AAG, NSC #330507) Daily X 5 in Patients With Advanced Cancer Therapeutic Protocol” NCT00004065 ↗

Action Inhibit “target inhibition (c-RAF-1 inhibition in four of six patients” PMID 15961763 ↗ Jun 2005
Route Intravenous “IV over 15-30 minutes” NCT00003969 ↗