Drugs / litronesib
Trials 7 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT01358019 | May 2011 → Jan 2013 | cancer | Kyowa Kirin, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT01214655 | Jun 2008 → Feb 2011 | acute leukemia | Eli Lilly and Company | Terminated | No outcome recorded |
| Phase 1 | NCT01214642 | May 2008 → Dec 2011 | — | Eli Lilly and Company | Completed | No outcome recorded |
| Phase 1 | NCT01214629 | Jul 2007 → May 2012 | cancer of unknown primary site, metastatic malignant neoplasm | Eli Lilly and Company | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT01416389 | Aug 2011 → Aug 2012 | breast cancer | Eli Lilly and Company | Completed | No outcome recorded |
| Phase 2 | NCT01059643 | Apr 2011 → Dec 2012 | colorectal cancer, esophageal cancer, gastric cancer, head and neck cancer +3 | Eli Lilly and Company | Completed | No outcome recorded |
| Phase 2 | NCT01025284 | Dec 2009 → Jul 2012 | small cell lung carcinoma | Eli Lilly and Company | Completed | No outcome recorded |
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | litronesib | “A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors.” PMID 24752449 ↗ Apr 2014 |
| Known as | KF 89617 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2105661 ↗ |
| Known as | LY2523355 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01025284 ↗ |
| Action | Inhibit | “LY2523355 (litronesib) is an allosteric inhibitor of Eg5.” PMID 24752449 ↗ Apr 20141“Kinesin-like protein 1 inhibitor” CHEMBL2105661 ↗ |
| Modality | Small molecule | — CHEMBL2105661 ↗ |
| Route | Intravenous | “Administered intravenously as a 1-hour infusion” NCT01025284 ↗ |
| Target | KIF11 | “Kinesin-like protein 1 inhibitor” CHEMBL2105661 ↗ |