Poractant alfa
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | CUROSURF | — | 2002-03-01 | fda.gov ↗ |
| Approved | US (FDA) | CUROSURF | — | 1999-11-18 | fda.gov ↗ |
Trials 19
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 35 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Poractant alfa | “Infants who on CPAP who reach the threshold of 30% oxygen will be randomized to calfactant (Infasurf), 3ml/kg or poractant alfa (Curosurf), 2.5ml/kg, administered under direct...” NCT06074380 ↗24“Preparations of poractantalfa (Curosurf, 200 mg/kg) (n = 15) or beractant (Survanta, 100 mg/kg) (n = 15) were administered in a consecutive randomized manner within the first 6...” NCT01923844 ↗ “200 mg/kg body weight nebulised surfactant (Poractant alfa, Chiesi Farmaceutici SpA, Parma, Italy) via a customised vibrating membrane nebuliser” NCT04315636 ↗ “Inhaled Nebulised Poractant Alfa (Porcine Surfactant, Curosurf®) In Comparison With Nasal Continuous Positive Airway Pressure (nCPAP) Alone” NCT03235986 ↗ “Poractant alfa and beractant treatment of very premature infants with respiratory distress syndrome.” PMID 20336076 ↗ Mar 2010 “REGISTRY NAME: Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome.” PMID 30690595 ↗ Oct 2019 “Infants received 200 mg/kg of poractant alfa (surfactant) or air after randomization.” PMID 26928567 ↗ Apr 2016 “porcine surfactant (poractant alfa, Curosurf®)” NCT02772081 ↗ |
| Known as | Curosurf | “Infants who on CPAP who reach the threshold of 30% oxygen will be randomized to calfactant (Infasurf), 3ml/kg or poractant alfa (Curosurf), 2.5ml/kg, administered under direct...” NCT06074380 ↗18“Chiesi Farmaceutici S.p.A (Chiesi) conducted this study with its porcine-derived surfactant, Curosurf® (poractant alfa), to evaluate the efficacy and safety in ventilated adult...” NCT04502433 ↗ “Preparations of poractantalfa (Curosurf, 200 mg/kg) (n = 15) or beractant (Survanta, 100 mg/kg) (n = 15) were administered in a consecutive randomized manner within the first 6...” NCT01923844 ↗ “Poractant alfa (Curosurf®, Chiesi Pharmaceuticals) administered intratracheally via the Less Invasive Surfactant Administration (LISA) technique over 1 minute.” NCT07261787 ↗ “Inhaled Nebulised Poractant Alfa (Porcine Surfactant, Curosurf®) In Comparison With Nasal Continuous Positive Airway Pressure (nCPAP) Alone” NCT03235986 ↗ “Poractant alfa (Curosurf) 200mg/kg administered under direct laryngoscopy using a surfactant instillation catheter” NCT06007547 ↗ “surfactant (Curosurf®, 2.5 ml/kg, Chiesi USA, Inc., Cary, NC) was administered” NCT01116921 ↗ “treatment with nebulized surfactant (Curosurf) or to serve as controls” PMID 10830460 ↗ Apr 2000 “Curosurf - a porcine surfactant routinely used for RDS” NCT03846960 ↗ “Poractant Alfa Intratracheal Suspension [Curosurf]” NCT04825197 ↗ “porcine surfactant (Poractant alfa, Curosurf ®)” NCT02452476 ↗ |
| Known as | Curosurf - a porcine surfactant routinely used for RDS | “Curosurf - a porcine surfactant routinely used for RDS” NCT03846960 ↗ |
| Known as | PORACTANT ALFA COMPONENT OF CHF-6440 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1201622 ↗ |
| Known as | poractant alfa;Curosurf | “Poractant alfa (curosurf)” NCT01852461 ↗1“poractant alfa;Curosurf” NCT04545866 ↗ |
| Known as | poractant alpha | “Patient receiving surfactant (3 mL/kg of a poractant alpha solution diluted to 16 mg/mL, resulting in a total dose of 48mg/kg) administred by bronchial fibroscopy. The total...” NCT04384731 ↗ |
| Modality | Other / unclassified | “surfactant application” NCT00751959 ↗ |
| Route | Other | “via a thin endotracheal catheter” NCT00751959 ↗ |