Drugs / olsalazine
olsalazine
also known as
Azodisal sodium · C. i. mordant yellow 5 · CJ 91B · Dipentum · Disodium azodisalicylate · Olsalazina · Olsalazine disodium salt · OLSALAZINE SODIUM · +2 more
Small molecule targets ALOX5, PPARG via inhibition / activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | DIPENTUM | — | 1990-07-31 | fda.gov ↗ |
Trials 1 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT00004288 | May 1996 → Dec 1999 | ankylosing spondylitis | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 3 | NCT01532648 Background | Jan 2012 → Oct 2013 | ulcerative colitis | Bausch Health Americas, Inc. | Completed | No outcome recorded |
Evidence & citations 16 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | olsalazine | “Dipentum® (generic: olsalazine), minimum daily dose ≥2.0 g” NCT01532648 ↗ |
| Known as | Azodisal sodium | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | C. i. mordant yellow 5 | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | CJ 91B | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | Dipentum | “Dipentum® (generic: olsalazine), minimum daily dose ≥2.0 g” NCT01532648 ↗ |
| Known as | Disodium azodisalicylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | Olsalazina | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | Olsalazine disodium salt | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | OLSALAZINE SODIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | Sodium azodisalicylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Known as | Sodium olsalazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL425 ↗ |
| Action | Activate | “Peroxisome proliferator-activated receptor gamma agonist” CHEMBL425 ↗ |
| Action | Inhibit | “Arachidonate 5-lipoxygenase inhibitor” CHEMBL425 ↗ |
| Modality | Small molecule | — CHEMBL425 ↗ |
| Target | ALOX5 | “Arachidonate 5-lipoxygenase inhibitor” CHEMBL425 ↗ |
| Target | PPARG | “Peroxisome proliferator-activated receptor gamma agonist” CHEMBL425 ↗ |