Drugs / Abediterol
last change Apr 2020 re-read 2 minutes ago

Abediterol

also known as AZD0548 · LAS100977

Small molecule targets ADRB2 via activation

Developed for
asthma · chronic obstructive pulmonary disease
Investigated by
AstraZeneca · Parexel

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT04199598 Jan → Apr 2020 chronic obstructive pulmonary disease AstraZeneca Terminated No outcome recorded
Phase 1 NCT03273127 Sep → Nov 2017 asthma AstraZeneca Completed No outcome recorded
Phase 1 NCT02967159 Nov 2016 → Apr 2017 asthma, chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded
Phase 1 NCT02777827 Jun → Nov 2016 asthma AstraZeneca Completed No outcome recorded
Phase 22 trials
Phase 2 NCT01425801 Aug 2011 → Feb 2012 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT01425814 Aug 2011 → Mar 2012 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Abediterol “BACKGROUND: Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination...” PMID 27439370 Jul 2016
5

“A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β2-adrenergic agonist, in asthma” PMID 25398689 Nov 2014

NCT02777827

NCT04199598

NCT02967159

NCT03273127

Known as AZD0548 “Abediterol (AZD0548) is a potential for once daily treatment of asthma and chronic obstructive pulmonary disease (COPD) in fixed dose combination (FDC) with an inhaled...” NCT02777827
Known as LAS100977 “A dose-ranging study of the bronchodilator effects of abediterol (LAS100977), a long-acting β2-adrenergic agonist, in asthma” PMID 25398689 Nov 2014
Action Activate “Abediterol is a novel and selective β2 adrenergic receptor agonist” NCT02967159
1

“Beta-2 adrenergic receptor agonist” CHEMBL3039530

Modality Small molecule CHEMBL3039530
Route Inhaled “Dry powder inhalation” NCT01425801
Target ADRB2 “Beta-2 adrenergic receptor agonist” CHEMBL3039530