Drugs / OLITIGALTIN
last change Apr 2025 re-read 2 minutes ago

OLITIGALTIN

also known as TD139 · GB0139 · Olitigaltina · Olitigaltine

Small molecule targets LGALS3 via inhibition

Developed for
COVID-19 · idiopathic pulmonary fibrosis
Investigated by
Galecto Biotech AB · Latus Therapeutics · Scottish National Blood Transfusion Service (SNBTS) · Syneos Health · University of Edinburgh · University of Oxford
+1 more · bioRASI, LLC

Trials 2 · a red edge is where a trial was stopped

20192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT04473053 Jul 2020 → Apr 2025 COVID-19 University of Edinburgh Completed No outcome recorded
Phase 21 trial
Phase 2 NCT03832946 Feb 2019 → May 2023 idiopathic pulmonary fibrosis Galecto Biotech AB Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT02257177 Comparator Sep 2014 → Dec 2016 idiopathic pulmonary fibrosis Galecto Biotech AB Completed No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as OLITIGALTIN ChEMBL registry synonym — accepted as the source's own label CHEMBL4297442
Known as GB0139 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03832946
Known as Olitigaltina ChEMBL registry synonym — accepted as the source's own label CHEMBL4297442
Known as Olitigaltine ChEMBL registry synonym — accepted as the source's own label CHEMBL4297442
Known as TD139 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02257177
1

NCT04473053

Action Inhibit “TD139 is a novel and potent small-molecule inhibitor of Gal-3.” PMID 33214209 May 2021
1

“Galectin-3 inhibitor” CHEMBL4297442

Modality Small molecule “TD139 is a novel and potent small-molecule inhibitor of Gal-3.” PMID 33214209 May 2021
Route Inhaled inhaled TD139 in 36 healthy subjects and 24 patients with IPF” PMID 33214209 May 2021
Target LGALS3 “Galectin-3 inhibitor” CHEMBL4297442