Drugs / VM202
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT00696124 | Apr 2007 → Oct 2009 | limb ischemia | Helixmith Co., Ltd. | Completed | No outcome recorded |
| Phase 1/24 trials | ||||||
| Phase 1/2 | NCT01002495 | Mar → Jul 2015 | myocardial ischemia | Helixmith Co., Ltd. | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT02039401 | Mar 2014 → Aug 2015 | amyotrophic lateral sclerosis | Helixmith Co., Ltd. | Completed | No outcome recorded |
| Phase 1/2 | NCT01002235 | Feb 2010 → Apr 2011 | diabetic polyneuropathy | Helixmith Co., Ltd. | Completed | No outcome recorded |
| Phase 1/2 | NCT01422772 | Jan 2007 → Feb 2010 | ischemic disease | Helixmith Co., Ltd. | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT04087941 | Nov 2019 → Dec 2022 | diabetic polyneuropathy | Brigham and Women's Hospital | Withdrawn | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT01064440 | Jul 2010 → Aug 2013 | limb ischemia | Helixmith Co., Ltd. | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 2 | NCT03363165 Comparator | Jan 2018 → Feb 2023 | peripheral arterial disease | Northwestern University | Completed | No outcome recorded |
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 8 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | VM202 | “VM202 is a DNA plasmid that contains novel genomic cDNA hybrid human hepatocyte growth factor (HGF) coding sequence (HGF-X7) expressing two isoforms of HGF, HGF 728 and HGF 723.” NCT04087941 ↗ |
| Known as | Engensis | “A Phase II, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy of VM202 (Engensis) in Subject With Critical Limb Ischemia” NCT01064440 ↗2“The purpose of this study is to evaluate the safety of VM202 (Engensis) direct injection into the cardiac muscles” NCT01422772 ↗ “injecting Engensis (VM202) in the leg muscle” NCT01002235 ↗ |
| Modality | Other / unclassified | “This study will use VM202, which is a DNA plasmid” NCT01064440 ↗ |
| Route | Intramuscular | “local intramuscular injection” NCT00696124 ↗ |