Drugs / Sotrovimab
last change Feb 2026 re-read 2 minutes ago

Sotrovimab

also known as VIR-7831 · GSK4182136 · SOT · Xevudy

Monoclonal antibody

Developed for
COVID-19 · nosocomial infection · pneumonia
Investigated by
GlaxoSmithKline · Vir Biotechnology, Inc. · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Cardiothoracic Surgical Trials Network · Eli Lilly and Company · International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)
+34 more · Kirby Institute · Medical Research Council · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Allergy and Infectious Diseases (NIAID) · Prevention and Early Treatment of Acute Lung Injury · US Department of Veterans Affairs · University of Copenhagen · University of Minnesota · Washington D.C. Veterans Affairs Medical Center · AbCellera Biologics Inc. · Addenbrookes Charitable Trust · Agenzia Italiana del Farmaco · AstraZeneca · Azienda Ospedaliera Universitaria Integrata Verona · Azienda Sanitaria-Universitaria Integrata di Udine · Brii Biosciences Limited · Cambridge University Hospitals NHS Foundation Trust · Dana-Farber Cancer Institute · Erin McCreary · Fred Hutchinson Cancer Center · Kidney Research UK (KRUK) · LifeArc · Massachusetts General Hospital · Molecular Partners AG · National Institute for Health Research, United Kingdom · National Marrow Donor Program · Pfizer · Shanghai Junshi Bioscience Co., Ltd. · Sophia Koo, M.D. · Sunnybrook Research Institute · UNION therapeutics · University of Calgary · University of Oxford · University of Pittsburgh

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Xevudy 2026-02-18 europa.eu

Trials 16 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT05280717 Mar 2022 → Apr 2023 COVID-19 Vir Biotechnology, Inc. Terminated No outcome recorded
Phase 1 NCT05135650 Jan → Oct 2022 COVID-19, cancer, hematopoietic and lymphoid cell neoplasm Fred Hutchinson Cancer Center Terminated No outcome recorded
Phase 1 NCT04988152 Jul → Sep 2021 COVID-19 Vir Biotechnology, Inc. Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05210101 Feb 2022 → Feb 2023 COVID-19 Sophia Koo, M.D. Completed No outcome recorded
Phase 2 NCT05124210 Dec 2021 → Jun 2023 COVID-19 GlaxoSmithKline Terminated No outcome recorded
Phase 2 NCT05041907 Sep 2021 → Jan 2027 expected COVID-19 University of Oxford Recruiting No outcome recorded
Phase 2 NCT04634409 Oct 2020 → Jul 2021 COVID-19 Eli Lilly and Company Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT04870333 Feb 2021 → Apr 2025 COVID-19 Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
Phase 2/3 NCT04545060 Aug 2020 → Apr 2021 COVID-19 Vir Biotechnology, Inc. Completed No outcome recorded
Phase 34 trials
Phase 3 NCT05205759 Dec 2021 → Feb 2022 COVID-19 Azienda Ospedaliera Universitaria Integrata Verona Terminated No outcome recorded
Phase 3 NCT04913675 Jun 2021 → Jul 2022 COVID-19 Vir Biotechnology, Inc. Terminated No outcome recorded
Phase 3 NCT05780281 Dec 2020 → Jun 2021 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT04501978 Aug 2020 → Apr 2022 COVID-19 National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 42 trials
Phase 4 NCT04790786 Mar 2021 → Jun 2022 COVID-19 Erin McCreary Terminated No outcome recorded
Phase 4 NCT04748588 Feb 2021 → Jan 2022 COVID-19, nosocomial infection University of Calgary Terminated No outcome recorded
Phase not stated1 trial
NCT05235347 COVID-19 Vir Biotechnology, Inc. No longer available No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT04746183 Comparator Jul 2020 → Mar 2027 expected COVID-19 University of Liverpool Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT04779879 Comparator Feb → Aug 2021 COVID-19 Vir Biotechnology, Inc. Completed No outcome recorded
Phase 33 trials
Phase 3 NCT05271929 Background Apr 2022 → Jan 2024 COVID-19 German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen Terminated No outcome recorded
Phase 3 NCT05321394 Comparator Mar 2022 → Oct 2023 COVID-19 Azienda Ospedaliera Universitaria Integrata Verona Completed No outcome recorded
Phase 3 NCT04381936 Comparator Mar 2020 → Sep 2028 expected pneumonia University of Oxford Recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT05305651 Background Jul 2022 → Jul 2023 COVID-19 GlaxoSmithKline Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 24 sources stand behind the page.

FieldValueCited text
Known as Sotrovimab “Casirivimab/imdesimab 1200mg/1200mg OR sotrovimab 500mg OR bamlanivimab 700mg IV x1.” NCT04748588
17

Sotrovimab (Xevudy)” NCT05271929

NCT05135650

NCT05321394

NCT05305651

NCT04381936

NCT05210101

NCT04870333

NCT04913675

NCT05041907

NCT04988152

NCT05124210

NCT04545060

NCT05235347

NCT05280717

NCT04779879

NCT05205759

NCT04790786

Known as GSK4182136 “Sotrovimab, VIR-7831, GSK4182136 Sterile solution for intravenous infusion, 62.5 mg/mL, intravenous infusion” NCT04870333
Known as SOT “500 mg of intravenous sotrovimab (SOT)” PMID 39343244 Sep 2024
Known as VIR-7831 “This is a phase 2 study in which subjects with coronavirus disease 2019 (COVID-19) will receive VIR-7831 (Sotrovimab) Generation 1 (Gen1) or VIR-7831 (Sotrovimab) Generation 2...” NCT04779879
6

“Sotrovimab, VIR-7831, GSK4182136 Sterile solution for intravenous infusion, 62.5 mg/mL, intravenous infusion” NCT04870333

VIR-7831 (sotrovimab) given by intravenous infusion (single dose)” NCT04545060

NCT04501978

NCT04634409

NCT04746183

NCT05780281

Known as Xevudy “Sotrovimab (Xevudy)” NCT05271929
Action Inhibit “neutralising monoclonal antibody” PMID 40886716 Aug 2025
Modality Monoclonal antibody “neutralising monoclonal antibodyPMID 40886716 Aug 2025
Route Intravenous “by intravenous infusion” NCT04381936