Drugs / Frovatriptan
Frovatriptan
also known as
Allergo filmtabletten · Frova · Frova(R) · FROVATRIPTAN SUCCINATE · Frovatriptan succinate hydrate · Frovatriptan succinate monohydrate · Frovelan · Migard · +5 more
Small molecule targets HTR1B, HTR1D via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | FROVA | — | 2001-11-08 | fda.gov ↗ |
Trials 6 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT01044251 | Jan 2010 → Apr 2019 | — | University of Calgary | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT00475514 | Oct 2004 → Mar 2006 | migraine disorder | Endo USA Inc., a Keenova Therapeutics Company | Completed | No outcome recorded |
| Phase 3 | NCT01035983 | Dec 2003 → Jun 2005 | migraine disorder | Endo USA Inc., a Keenova Therapeutics Company | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT00904098 | Sep 2005 → Feb 2006 | migraine disorder | Endo USA Inc., a Keenova Therapeutics Company | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT00700128 | Jun 2008 → Jan 2010 | hemorrhagic disease, migraine disorder | Scott and White Hospital & Clinic | Completed | No outcome recorded |
| — | NCT00440232 | Jul 2007 → Mar 2009 | migraine disorder | Thomas Jefferson University | Completed | No outcome recorded |
Also used as a comparator or background therapy in 3 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 32 trials | ||||||
| Phase 3 | NCT00821483 Comparator | Nov 2006 → Feb 2008 | migraine disorder | SK Chemicals Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT00644033 Comparator | Jun 2001 → Jun 2002 | migraine disorder | Endo USA Inc., a Keenova Therapeutics Company | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT00846495 Comparator | Aug 2009 → Jan 2011 | migraine disorder | Clinvest | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 11 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Frovatriptan | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00440232 ↗ |
| Known as | Allergo filmtabletten | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Frova | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Frova(R) | “OBJECTIVE: To assess the safety and tolerability profile of the 5-HT(1B/1D) agonist frovatriptan (Frova(R), Endo Pharmaceuticals Inc., Chadds Ford, PA, USA)” PMID 19788471 ↗ Oct 2009 |
| Known as | FROVATRIPTAN SUCCINATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Frovatriptan succinate hydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Frovatriptan succinate monohydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Frovelan | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Migard | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Miguard | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | Mylatrip | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | NSC-760422 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | SB 209509 AX | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Known as | VML 251 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1279 ↗ |
| Action | Activate | “Serotonin 1d (5-HT1d) receptor agonist” CHEMBL1279 ↗2“Serotonin 1b (5-HT1b) receptor agonist” CHEMBL1279 ↗ “5-HT(1B/1D) agonist” PMID 19788471 ↗ Oct 2009 |
| Modality | Small molecule | — CHEMBL1279 ↗ |
| Route | Oral | “orally” NCT00440232 ↗ |
| Target | HTR1B | “Serotonin 1b (5-HT1b) receptor agonist” CHEMBL1279 ↗ |
| Target | HTR1D | “Serotonin 1d (5-HT1d) receptor agonist” CHEMBL1279 ↗ |