Drugs / STEMVAC
last change Jul 2026 re-read 2 minutes ago

STEMVAC

Vaccine targets CDH3, MDM2, SOX2 via depletion

Developed for
female breast carcinoma · triple-negative breast carcinoma
Investigated by
University of Washington · Kuni Foundation · National Cancer Institute (NCI) · University of Wisconsin, Madison

Trials 2 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT07078604 Mar 2026 → Apr 2027 expected female breast carcinoma, triple-negative breast carcinoma University of Washington Recruiting No outcome recorded
Phase 2 NCT05455658 Nov 2022 → Jul 2026 overdue female breast carcinoma, triple-negative breast carcinoma University of Washington Active not recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as STEMVAC “This phase II trial studies the effect of DNA plasmid based vaccine (STEMVAC) in treating patients with patients with stage IB-III triple negative breast cancer.” NCT05455658
1

“This phase II trial studies how well a cancer vaccine called STEMVAC works in combination with chemotherapy” NCT07078604

Action Deplete “it is believed to work by boosting the immune system to recognize and destroy the invader tumor cells that are causing the disease” NCT07078604
Modality Vaccine “DNA plasmid based vaccine (STEMVAC)” NCT05455658
Route Intravenous “Given IV” NCT05455658
Target CDH3 “A Phase II Trial of the Immunogenicity of a DNA Plasmid-Based Vaccine (STEMVAC) Encoding Th1 Selective Epitopes From Five Antigens Associated With Breast Cancer Stem Cells...” NCT07078604
Target MDM2 “A Phase II Trial of the Immunogenicity of a DNA Plasmid-Based Vaccine (STEMVAC) Encoding Th1 Selective Epitopes From Five Antigens Associated With Breast Cancer Stem Cells...” NCT07078604
Target SOX2 “A Phase II Trial of the Immunogenicity of a DNA Plasmid-Based Vaccine (STEMVAC) Encoding Th1 Selective Epitopes From Five Antigens Associated With Breast Cancer Stem Cells...” NCT07078604