Drugs / 5-Methyltetrahydrofolate
last change Apr 2026 re-read 2 minutes ago

5-Methyltetrahydrofolate

also known as 5-MTHF

Other / unclassified

Developed for
optic nerve disorder · type 1 diabetes mellitus
Investigated by
Mayo Clinic · National Aeronautics and Space Administration (NASA) · Shanghai Changzheng Hospital · Texas A&M University

Trials 2 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT05366933 Aug 2022 → Jul 2027 expected optic nerve disorder National Aeronautics and Space Administration (NASA) Recruiting No outcome recorded
Phase not applicable1 trial
NCT06930144 Apr 2025 → Apr 2026 overdue type 1 diabetes mellitus Shanghai Changzheng Hospital Not yet recruiting No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as 5-methyltetrahydrofolate “Vitamin B-Complex Supplement containing: 5-methyltetrahydrofolate, riboflavin 5 phosphate, pyridoxal phosphate, and methylcobalamin” NCT05366933
1

5-Methyltetrahydrofolate (5-MTHF) can prevent oxidative loss of” PMID 37482222 Jul 2023

Known as 5-MTHF “5-Methyltetrahydrofolate (5-MTHF) can prevent oxidative loss of” PMID 37482222 Jul 2023
Modality Other / unclassified “daily nutraceutical supplement containing bioactive B vitamins” NCT05366933
Route Oral “Daily oral intake of active folate 800ug combined with basic diabetic treatment” NCT06930144