Drugs / RUSERONTINIB
last change Dec 2025 re-read 2 minutes ago

RUSERONTINIB

also known as SKLB1028

Small molecule targets ABL1, EGFR, FLT3 via inhibition

Developed for
acute myeloid leukemia · cancer
Investigated by
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Trials 9 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT05072522 Oct 2021 → Oct 2023 cancer CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown No outcome recorded
Phase 1 NCT05369858 Aug → Sep 2021 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Completed No outcome recorded
Phase 1 NCT05069870 Jun → Nov 2021 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown No outcome recorded
Phase 1 NCT05070195 Jun → Jul 2021 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Completed No outcome recorded
Phase 1 NCT05109663 Apr → Jun 2021 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Completed No outcome recorded
Phase 1 NCT02859948 May 2016 → Dec 2017 acute myeloid leukemia CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT05445154 Aug 2021 → Oct 2024 overdue acute myeloid leukemia CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT04015024 Jul 2019 → Apr 2021 acute myeloid leukemia CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown No outcome recorded
Phase 31 trial
Phase 3 NCT04716114 Mar 2021 → Dec 2025 acute myeloid leukemia CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as RUSERONTINIB ChEMBL registry synonym — accepted as the source's own label CHEMBL3678958
Known as SKLB1028 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05069870
8

NCT05109663

NCT05445154

NCT05369858

NCT04015024

NCT05072522

NCT02859948

NCT04716114

NCT05070195

Action Inhibit “Epidermal growth factor receptor erbB1 inhibitor” CHEMBL3678958
2

“Tyrosine-protein kinase receptor FLT3 inhibitor” CHEMBL3678958

“Tyrosine-protein kinase ABL inhibitor” CHEMBL3678958

Modality Small molecule CHEMBL3678958
Route Oral “Patients will receive oral SKLB1028 for 28 days” NCT02859948
Target ABL1 “Tyrosine-protein kinase ABL inhibitor” CHEMBL3678958
Target EGFR “Epidermal growth factor receptor erbB1 inhibitor” CHEMBL3678958
Target FLT3 “Tyrosine-protein kinase receptor FLT3 inhibitor” CHEMBL3678958