drugset
Drugs / Hypericum perforatum
last change Aug 2025 re-read 3 minutes ago

Hypericum perforatum

English name St. John's Wort
also known as St. John's wort · H. perforatum · hypericum · LI-160 · St. John's wort oil

Traditional medicine (herbal / TCM)

Developed for
anxiety disorder · aphthous stomatitis · attention deficit-hyperactivity disorder · major depressive disorder
Investigated by
National Center for Complementary and Integrative Health (NCCIH) · Alliance for Clinical Trials in Oncology · Batman University · National Cancer Institute (NCI) · National Institute of Mental Health (NIMH) · University Hospital, Grenoble

Trials 7

today NCT06839313 · not/applicable NCT00100295 · Ph 2 NCT00222365 · Ph 3 NCT00118833 · Ph 2/3 NCT00026013 · not/applicable NCT00005013 · not/applicable
19992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial · 1 missed
Phase 2 NCT00100295 Feb 2005 → Nov 2006 attention deficit-hyperactivity disorder National Center for Complementary and Integrative Health (NCCIH) Completed Missed primary
Phase 2/31 trial
Phase 2/3 NCT00118833 Aug 2002 → Jun 2006 anxiety disorder National Center for Complementary and Integrative Health (NCCIH) Completed No outcome recorded
Phase 32 trials
Phase 3 NCT00222365 Dec 2003 → May 2006 — University Hospital, Grenoble Terminated No outcome recorded
Phase 3 NCT00041171 — breast cancer, head and neck cancer, malignant urinary system neoplasm, reproductive system cancer +1 Alliance for Clinical Trials in Oncology Withdrawn No outcome recorded
Phase not applicable3 trials · 1 missed
— NCT06839313 Feb → Aug 2025 aphthous stomatitis Batman University Completed No outcome recorded
— NCT00026013 Jan 2002 → Jan 2004 — National Center for Complementary and Integrative Health (NCCIH) Completed No outcome recorded
— NCT00005013 Dec 1998 → Jul 2001 major depressive disorder National Institute of Mental Health (NIMH) Completed Missed primary

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Hypericum Perforatum “Phase III Randomized Study of Hypericum Perforatum (St. John's Wort) Combined With Docetaxel in Patients With Unresectable Solid Tumors” NCT00041171 ↗
7

NCT00026013 ↗

NCT00041171 ↗

NCT00118833 ↗

NCT00100295 ↗

NCT06839313 ↗

NCT00005013 ↗

NCT00222365 ↗
Known as H. perforatum “OBJECTIVE: To test the efficacy and safety of a well-characterized H perforatum extract (LI-160) in major depressive disorder.” PMID 11939866 ↗ Apr 2002
Known as hypericum “The purpose of this trial is to study the acute efficacy and safety of a standardized extract of the herb Hypericum perforatum (St. John's Wort), called hypericum for purposes...” NCT00005013 ↗
Known as LI-160 “OBJECTIVE: To test the efficacy and safety of a well-characterized H perforatum extract (LI-160) in major depressive disorder.” PMID 11939866 ↗ Apr 2002
Known as St. John's wort “The purpose of this trial is to study the acute efficacy and safety of a standardized extract of the herb Hypericum perforatum (St. John's Wort), called hypericum for purposes...” NCT00005013 ↗
3

“The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills.” NCT00026013 ↗

“Phase III Randomized Study of Hypericum Perforatum (St. John's Wort) Combined With Docetaxel in Patients With Unresectable Solid Tumors” NCT00041171 ↗

“Hypericum perforatum (St. John's wort)” NCT00118833 ↗
Known as St. John's wort oil “Hypericum perforatum (St. John's wort oil, Zade Vital; Health&Fitness, Developed With Ege Üniversiesi Argefar)” NCT06839313 ↗
Modality Traditional medicine (herbal / TCM) “common herbal remedy” NCT00026013 ↗
Route Oral “Patients receive oral Hypericum perforatum three times daily on days 1-14 and docetaxel as in arm I.” NCT00041171 ↗