Drugs / TADNERSEN SODIUM
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT04288856 | Apr 2020 → May 2022 | amyotrophic lateral sclerosis | Biogen | Terminated | No outcome recorded |
| Phase 1 | NCT03626012 | Sep 2018 → Nov 2021 | amyotrophic lateral sclerosis | Biogen | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 2
| Date | Issuer | Release |
|---|---|---|
| 2022-03-28 | Ionis Pharmaceuticals | Results Biogen and Ionis Announce Topline Phase 1 Study Results of Investigational Drug in C9orf72 Amyotrophic Lateral Sclerosis ionis.com ↗ |
| 2022-03-28 | Biogen | Results Biogen and Ionis Announce Topline Phase 1 Study Results of Investigational Drug in C9orf72 Amyotrophic Lateral Sclerosis biogen.com ↗
BIIB078 did not meet any secondary efficacy endpoints and it did not demonstrate clinical benefit. |
All press releases naming this drug 2 releases
| Date | Issuer | Release |
|---|---|---|
| 2022-03-28 | Ionis Pharmaceuticals | Biogen and Ionis Announce Topline Phase 1 Study Results of Investigational Drug in C9orf72 Amyotrophic Lateral Sclerosis ionis.com ↗ |
| 2022-03-28 | Biogen | Biogen and Ionis Announce Topline Phase 1 Study Results of Investigational Drug in C9orf72 Amyotrophic Lateral Sclerosis biogen.com ↗ |
Evidence & citations 5 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | TADNERSEN SODIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL4650451 ↗ |
| Known as | BIIB078 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03626012 ↗ |
| Modality | Antisense oligonucleotide | “antisense oligonucleotide BIIB078” PMID 39059407 ↗ Jul 2024 |
| Route | Intrathecal | “via an intrathecal bolus injection” PMID 39059407 ↗ Jul 2024 |
| Target | C9ORF72 | “BIIB078 is an investigational antisense oligonucleotide targeting C9orf72 sense RNA.” PMID 39059407 ↗ Jul 2024 |