Drugs / LY2452473
last change Oct 2020 re-read 2 minutes ago

LY2452473

also known as OPK-88004 · TT-701

Small molecule targets AR via activation

Developed for
benign prostatic hyperplasia · erectile dysfunction · prostate cancer
Investigated by
Eli Lilly and Company · OPKO Health, Inc.

Trials 3 · a red edge is where a trial was stopped

20112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01275157 Jan → Feb 2011 Eli Lilly and Company Completed No outcome recorded
Phase 22 trials
Phase 2 NCT03297398 Feb 2018 → Apr 2019 benign prostatic hyperplasia OPKO Health, Inc. Terminated No outcome recorded
Phase 2 NCT01160289 Oct 2010 → Nov 2011 erectile dysfunction Eli Lilly and Company Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01401543 Comparator Jul → Sep 2011 erectile dysfunction Eli Lilly and Company Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02499497 Comparator Feb 2016 → Oct 2020 prostate cancer Dana-Farber Cancer Institute Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as LY2452473 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01401543
3

NCT01275157

NCT01160289

NCT02499497

Known as OPK-88004 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03297398
Known as TT-701 ChEMBL registry synonym — accepted as the source's own label CHEMBL3542265
Action Activate “which is agonist on the muscle” NCT02499497
Modality Small molecule “Selective Androgen Receptor Modulator” NCT03297398
1

CHEMBL3542265

Route Oral “Administered orally, once daily for 12 weeks” NCT01160289
Target AR “LY2452473 is a selective androgen receptor modulator” NCT02499497