Drugs / Olorinab
last change Jan 2022 re-read 3 minutes ago

Olorinab

also known as APD-371

Small molecule targets CNR2 via activation

Developed for
irritable bowel syndrome · Crohn disease
Investigated by
Arena Pharmaceuticals

Trials 3

2018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04655599 Jan → Apr 2021 irritable bowel syndrome Arena Pharmaceuticals Terminated No outcome recorded Stop: Business
Phase 22 trials · 1 missed
Phase 2 NCT04043455 Jul 2019 → Apr 2021 irritable bowel syndrome Arena Pharmaceuticals Terminated Missed primary Stop: Business
Phase 2 NCT03155945 Jul 2017 → Sep 2018 Crohn disease Arena Pharmaceuticals Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Olorinab ClinicalTrials.gov intervention name — accepted as the source's own label NCT04655599 ↗
2

NCT03155945 ↗

NCT04043455 ↗

Known as APD-371 ChEMBL registry synonym — accepted as the source's own label CHEMBL4175981 ↗
Action Activate “a highly selective, full agonist of the cannabinoid receptor 2” PMID 33863856 ↗ Jan 2022
1

“Cannabinoid CB2 receptor agonist” CHEMBL4175981 ↗

Modality Small molecule — CHEMBL4175981 ↗
Route Oral “Participants received olorinab 100 mg oral tablets TID for 8 weeks” NCT03155945 ↗
Target CNR2 “Cannabinoid CB2 receptor agonist” CHEMBL4175981 ↗