Drugs / Pozelimab

Trials 21 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06479863 Aug 2024 → May 2027 expected idiopathic inflammatory myopathy, inclusion body myositis Austin Neuromuscular Center Recruiting No outcome recorded
Phase 15 trials
Phase 1 NCT07230834 Jan 2026 → Jul 2028 expected dry age related macular degeneration Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase 1 NCT04940364 Aug 2021 → Jun 2022 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT04601844 Nov 2020 → Jul 2021 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT04491838 Aug 2020 → Mar 2021 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT03115996 May 2017 → Aug 2018 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 23 trials
Phase 2 NCT04811716 Jul 2021 → Oct 2022 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Completed No outcome recorded
Phase 2 NCT04888507 Jul 2021 → May 2022 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Completed No outcome recorded
Phase 2 NCT03946748 May 2019 → Jun 2021 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04209634 Jan 2020 → Nov 2021 protein-losing enteropathy Regeneron Pharmaceuticals Completed No outcome recorded
Phase 37 trials
Phase 3 NCT07154745 Jun 2026 → Jan 2030 expected paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06541704 Oct 2024 → Nov 2027 expected dry age related macular degeneration Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT05744921 Mar 2023 → Feb 2029 expected paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT05131204 Oct 2022 → Jul 2023 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Terminated No outcome recorded
Phase 3 NCT05133531 Aug 2022 → Oct 2026 expected paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Active not recruiting No outcome recorded
Phase 3 NCT05070858 Dec 2021 → Jul 2025 overdue generalized myasthenia gravis Regeneron Pharmaceuticals Active not recruiting No outcome recorded
Phase 3 NCT04162470 Dec 2019 → Apr 2022 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals Terminated No outcome recorded
Phase 41 trial
Phase 4 NCT07142343 Mar 2026 → Feb 2030 expected Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase not stated3 trials
NCT05232110 protein-losing enteropathy Regeneron Pharmaceuticals Approved for marketing No outcome recorded
NCT06003881 protein-losing enteropathy Regeneron Pharmaceuticals Approved for marketing No outcome recorded
NCT06028594 paroxysmal nocturnal hemoglobinuria Regeneron Pharmaceuticals No longer available No outcome recorded

Press releases naming this drug 4 releases

DateIssuerRelease
2024-12-07 Regeneron Pharmaceuticals Novel Combination of Pozelimab and Cemdisiran (Poze-Cemdi) Achieved Greater Control of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria Compared to Ravulizumab regeneron.com
2023-08-18 Regeneron Pharmaceuticals Veopoz™ (pozelimab-bbfg) Receives FDA Approval as the First Treatment for Children and Adults with CHAPLE Disease regeneron.com
2023-02-21 Regeneron Pharmaceuticals Pozelimab (C5 Antibody) BLA for Treatment of Children and Adults with Ultra-rare CHAPLE Disease Accepted for FDA Priority Review regeneron.com
2019-12-05 Regeneron Pharmaceuticals Regeneron Announces Positive Topline Phase 2 Data with Anti-C5 Antibody Pozelimab in Patients with a Rare Blood Disorder regeneron.com

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 24 sources stand behind the page.

FieldValueCited text
Known as Pozelimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT06479863
17

NCT04888507

NCT04811716

NCT04940364

NCT07230834

NCT05232110

NCT05070858

NCT04209634

NCT06003881

NCT04491838

NCT07154745

NCT05133531

NCT07142343

NCT05131204

NCT06028594

NCT05744921

NCT06541704

NCT04601844

Known as Pozelimab-bbfg ChEMBL registry synonym — accepted as the source's own label CHEMBL4298086
Known as REGN3918 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03946748
2

NCT04162470

NCT03115996

Known as Veopoz ChEMBL registry synonym — accepted as the source's own label CHEMBL4298086
Action Inhibit “an antibody blocking complement component 5” PMID 38278170 Jan 2024
Modality Monoclonal antibody “Intravenously and Subcutaneously Administered Human Monoclonal Antibody REGN3918” NCT03115996
Route Intravenous Intravenously and Subcutaneously Administered Human Monoclonal Antibody REGN3918” NCT03115996
Route Subcutaneous “Intravenously and Subcutaneously Administered Human Monoclonal Antibody REGN3918” NCT03115996
Target C5 “a C5 antibody (pozelimab)” PMID 42030965 Apr 2026