Drugs / Trifluoperazine
Trifluoperazine
also known as
Amylozine · Apo-trifluoperazine · Flurazine · NSC-17474 · NSC-46061 · NSC-757369 · RP-7623 · Stelazine · +6 more
Small molecule targets HTR2A, HTR2C via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | STELAZINE | — | 1959-04-16 | fda.gov ↗ |
Trials 3
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT03966053 | Sep 2019 → Oct 2021 | Diamond-Blackfan anemia | Adrianna Vlachos, MD | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT07008235 | Jul 2025 → Jun 2026 overdue | dyspepsia | Md. Moktadirul Hoque Shuvo | Recruiting | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT01765829 | Nov 2012 → Nov 2015 | psychotic disorder | Fundación Pública Andaluza Progreso y Salud | Unknown | No outcome recorded |
Evidence & citations 20 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Trifluoperazine | “Drugs: Aripiprazole, Olanzapine, Zuclopenthixol, Clotiapine, Flupentixol, Risperidone, Sulpiride, Trifluoperazine, Haloperidol, Quetiapine, Paliperidone, Chlorpromazine,...” NCT01765829 ↗ |
| Known as | Amylozine | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Apo-trifluoperazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Flurazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | NSC-17474 | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | NSC-46061 | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | NSC-757369 | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | RP-7623 | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Stelazine | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Stelazine fte | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | TFP | “Trifluoperazine (TFP)1mg, 2mg, 5mg, or 10mg will be given once daily by mouth for 21 days” NCT03966053 ↗ |
| Known as | Trifluoperazina | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Trifluoperazine dihydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | Trifluoperazine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Known as | TRIFLUOPERAZINE HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL422 ↗ |
| Action | Inhibit | “Using the RP deficient zebrafish embryo model, high throughput drug screens have demonstrated a strong hematologic response to several calmodulin inhibitors. One of these...” NCT03966053 ↗2“Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL422 ↗ “Serotonin 2c (5-HT2c) receptor antagonist” CHEMBL422 ↗ |
| Modality | Small molecule | “One of these chemicals is trifluoperazine (TFP).” NCT03966053 ↗ |
| Route | Oral | “will be given once daily by mouth” NCT03966053 ↗ |
| Target | HTR2A | “Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL422 ↗ |
| Target | HTR2C | “Serotonin 2c (5-HT2c) receptor antagonist” CHEMBL422 ↗ |