Drugs / IDRX-42
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IDRX-42

also known as Velzatinib · GSK6042981 · M-4205

Small molecule

Developed for
gastrointestinal stromal tumor · metastatic malignant neoplasm
Investigated by
GlaxoSmithKline · GSK

Trials 4 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT05489237 Aug 2022 → Mar 2027 expected gastrointestinal stromal tumor, metastatic malignant neoplasm GSK Active not recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT07689201 Aug 2026 → Dec 2027 expected gastrointestinal stromal tumor GlaxoSmithKline Not yet recruiting No outcome recorded
Phase 32 trials
Phase 3 NCT07585266 Jul 2026 → Sep 2032 expected gastrointestinal stromal tumor GlaxoSmithKline Not yet recruiting No outcome recorded
Phase 3 NCT07218926 Dec 2025 → May 2028 expected gastrointestinal stromal tumor GlaxoSmithKline Recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as IDRX-42 “The goal of this study is to evaluate the study drug velzatinib (GSK6042981 / IDRX-42) to see whether velzatinib can shrink or control tumors and is safe and tolerated in Japan...” NCT07689201
2

NCT07218926

NCT05489237

Known as GSK6042981 “A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy” NCT07218926
Known as M-4205 ChEMBL registry synonym — accepted as the source's own label CHEMBL5314917
Known as Velzatinib ClinicalTrials.gov intervention name — accepted as the source's own label NCT07585266
1

NCT07689201

Action Inhibit “tyrosine kinase inhibitor” NCT05489237
Modality Small molecule small moleculeNCT05489237
Route Oral orally administered” NCT05489237