Drugs / GANCOTAMAB
last change Jun 2018 re-read 2 minutes ago

GANCOTAMAB

also known as MM-302

Other / unclassified targets ERBB2, TOP2A via inhibition

Developed for
breast cancer · HER2 positive breast carcinoma · metastatic malignant neoplasm in the brain
Investigated by
Merrimack Pharmaceuticals · Pamela Munster

Trials 3 · a red edge is where a trial was stopped

20112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02735798 Apr 2016 → Jun 2017 metastatic malignant neoplasm in the brain Pamela Munster Withdrawn No outcome recorded
Phase 11 trial
Phase 1 NCT01304797 Mar 2011 → Aug 2016 breast cancer Merrimack Pharmaceuticals Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02213744 Jul 2014 → Dec 2016 HER2 positive breast carcinoma Merrimack Pharmaceuticals Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as GANCOTAMAB ChEMBL registry synonym — accepted as the source's own label CHEMBL3833344
Known as MM-302 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02735798
2

NCT01304797

NCT02213744

Action Inhibit “DNA topoisomerase II alpha inhibitor” CHEMBL3833344
Modality Other / unclassified “64Cu-labeled HER2-targeted PEGylated liposomal doxorubicin” PMID 28298546 Mar 2017
Route Intravenous Intravenously Administered MM-302” NCT01304797
Target ERBB2 “Receptor protein-tyrosine kinase erbB-2 binding agent” CHEMBL3833344
Target TOP2A “DNA topoisomerase II alpha inhibitor” CHEMBL3833344