Drugs / Dutogliptin
last change Sep 2025 re-read 2 minutes ago

Dutogliptin

Small molecule targets DPP4 via inhibition

Developed for
type 2 diabetes mellitus · myocardial ischemia · ST-elevation myocardial infarction
Investigated by
Phenomix · Forest Laboratories

Trials 9 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT01101945 Jul 2007 → Jan 2010 type 2 diabetes mellitus Phenomix Terminated No outcome recorded
Phase 2 NCT00482950 Apr 2007 → Feb 2008 type 2 diabetes mellitus Phenomix Unknown No outcome recorded
Phase 37 trials
Phase 3 NCT01089790 Mar → Aug 2010 type 2 diabetes mellitus Forest Laboratories Terminated No outcome recorded
Phase 3 NCT00998686 Nov 2009 → Oct 2011 type 2 diabetes mellitus Phenomix Terminated No outcome recorded
Phase 3 NCT00970424 Aug 2009 → Aug 2010 type 2 diabetes mellitus Forest Laboratories Terminated No outcome recorded
Phase 3 NCT00958269 Aug 2009 → Sep 2011 impaired renal function disease, type 2 diabetes mellitus Phenomix Terminated No outcome recorded
Phase 3 NCT00850239 May 2009 → Oct 2010 type 2 diabetes mellitus Phenomix Terminated No outcome recorded
Phase 3 NCT00865592 Mar 2009 → Jan 2011 type 2 diabetes mellitus Phenomix Terminated No outcome recorded
Phase 3 NCT00690638 Jul 2008 → Jan 2010 type 2 diabetes mellitus Phenomix Completed No outcome recorded
Also used as a comparator or background therapy in 4 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT03486080 Comparator Dec 2018 → Feb 2021 ST-elevation myocardial infarction, myocardial ischemia Recardio, Inc. Completed No outcome recorded
Phase 2 NCT00530881 Comparator Apr → Oct 2006 type 2 diabetes mellitus Phenomix Completed No outcome recorded
Phase 32 trials
Phase 3 NCT05881382 Comparator Sep 2023 → Sep 2025 ST-elevation myocardial infarction Recardio, Inc. Unknown No outcome recorded
Phase 3 NCT00947557 Comparator Jul 2009 → Jul 2010 type 2 diabetes mellitus Forest Laboratories Terminated No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 14 sources stand behind the page.

FieldValueCited text
Known as Dutogliptin ClinicalTrials.gov intervention name — accepted as the source's own label NCT03486080
9

NCT05881382

NCT00970424

NCT00998686

NCT00958269

NCT00947557

NCT01089790

NCT00850239

NCT01101945

NCT00865592

Known as DUTOGLIPTIN TARTRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL4296719
Known as Dutogliptina ChEMBL registry synonym — accepted as the source's own label CHEMBL4296719
Known as Dutogliptine ChEMBL registry synonym — accepted as the source's own label CHEMBL4296719
Known as PHX1149 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00530881
Known as PHX1149T “The purpose of this study is to demonstrate that dutogliptin/PHX1149T is safe and tolerable.” NCT01101945
3

“dutogliptin/PHX1149TNCT00998686

NCT00482950

NCT00690638

Action Inhibit “The drug is a "DPP4 inhibitor"” NCT00530881
Modality Small molecule CHEMBL4296719
Route Oral oral administration once daily” NCT00947557
Target DPP4 “The drug is a "DPP4 inhibitor"” NCT00530881