Drugs / CARBAMOYLCHOLINE
CARBAMOYLCHOLINE
also known as
Carbachol · Carbachol chloride · CARBACHOL PF · Carbacol · Carbastat · Doryl · Miostat · NSC-32865
Small molecule targets CHRM3 via activation
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | MIOSTAT | — | 1995-08-18 | fda.gov ↗ |
| Approved | US (FDA) | MIOSTAT | — | 1972-09-28 | fda.gov ↗ |
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT06948357 | Mar → Sep 2025 overdue | presbyopia | Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. | Recruiting | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT00564408 | Aug 2007 → Oct 2008 | headache disorder | Danish Headache Center | Completed | No outcome recorded |
| Comparator or background therapy4 trials | ||||||
| Phase 2 | NCT04774237 Comparator | Mar → Oct 2021 | presbyopia | Visus Therapeutics | Completed | No outcome recorded |
| Phase 3 | NCT05270863 Comparator | Mar 2022 → Mar 2023 | presbyopia | Visus Therapeutics | Completed | Met primary |
| Phase 3 | NCT05135286 Comparator | Mar 2022 → Mar 2025 | presbyopia | Visus Therapeutics | Completed | No outcome recorded |
| — | NCT04274413 Background | Feb 2021 | CFTR-related disorder, cystic fibrosis | The Hospital for Sick Children | Withdrawn | No outcome recorded Stop: Business |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | CARBAMOYLCHOLINE | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | Carbachol | “Under the second probe, first injection carbachol will be given in one small area of the skin.” NCT04274413 ↗ |
| Known as | Carbachol chloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | CARBACHOL PF | “BRIMOCHOL PF eye drops, CARBACHOL PF eye drops, Brimonidine eye drops and Placebo were administered in 7 treatment sequences in various combinations and doses” NCT06948357 ↗ |
| Known as | Carbacol | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | Carbastat | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | Doryl | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | Miostat | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Known as | NSC-32865 | ChEMBL registry synonym — accepted as the source's own label CHEMBL965 ↗ |
| Action | Activate | “Muscarinic acetylcholine receptor M3 agonist” CHEMBL965 ↗ |
| Modality | Small molecule | — CHEMBL965 ↗ |
| Route | Intravenous | “infused intravenously” NCT00564408 ↗ |
| Target | CHRM3 | “Muscarinic acetylcholine receptor M3 agonist” CHEMBL965 ↗ |