drugset
Drugs / troglitazone
last change Apr 2000 re-read 3 minutes ago

troglitazone

also known as CI-991 · CS-045 · GR-92132X · Prelay · Rezulin · Romozin · Troglitazona

Small molecule targets PPARG

Developed for
atherosclerosis · diabetes mellitus · sarcoma
Investigated by
Dana-Farber Cancer Institute · National Cancer Institute (NCI) · Parke-Davis

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) PRELAY — 1999-10-01 fda.gov ↗
Label expansions (2) US (FDA) REZULIN — 1997-08-04 – 1999-06-16 fda.gov ↗
Approved US (FDA) PRELAY — 1997-01-29 fda.gov ↗

Trials 2

today
US approved 1997
NCT00003058 · Ph 2 NCT00116545 · Ph 2/3
1997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT00003058 Jun 1997 → Jan 2000 sarcoma Dana-Farber Cancer Institute Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00116545 Jan 1997 → Apr 2000 atherosclerosis, diabetes mellitus Parke-Davis Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as troglitazone ClinicalTrials.gov intervention name — accepted as the source's own label NCT00003058 ↗
1

NCT00116545 ↗
Known as CI-991 ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as CS-045 ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as GR-92132X ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as Prelay ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as Rezulin ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as Romozin ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Known as Troglitazona ChEMBL registry synonym — accepted as the source's own label CHEMBL408 ↗
Modality Small molecule — CHEMBL408 ↗
Route Oral “Patients received troglitazone 800 mg oral once-daily.” NCT00003058 ↗
Target PPARG “the peroxisome proliferator-activated receptor-gamma ligand troglitazone” PMID 10097144 ↗ Mar 1999