drugset
Drugs / Atopaxar
last change Aug 2011 re-read 2 minutes ago

Atopaxar

also known as E5555 · ATOPAXAR HYDROBROMIDE · E-5555 HBR · ER-172594-00 · ER-172594-06

Small molecule targets F2R via inhibition

Developed for
coronary artery disorder · acute coronary syndrome
Investigated by
Eisai Inc.

Trials 5 · a red edge is where a trial was stopped

today NCT01261156 · Ph 1 NCT01241669 · Ph 1 NCT00619164 · Ph 2 NCT00540670 · Ph 2 NCT00312052 · Ph 2
20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01261156 Oct → Dec 2010 — Eisai Inc. Completed No outcome recorded
Phase 1 NCT01241669 Oct 2010 → Aug 2011 — Eisai Inc. Completed No outcome recorded
Phase 23 trials
Phase 2 NCT00619164 Nov 2007 → Sep 2009 acute coronary syndrome Eisai Inc. Completed No outcome recorded
Phase 2 NCT00540670 Oct 2007 → Mar 2009 coronary artery disorder Eisai Inc. Completed No outcome recorded
Phase 2 NCT00312052 Sep 2007 → Mar 2008 coronary artery disorder Eisai Inc. Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT00548587 Comparator Oct 2007 → Apr 2009 acute coronary syndrome Eisai Inc. Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as Atopaxar “Atopaxar (E5555) is a reversible protease-activated receptor-1 thrombin receptor antagonist that interferes with platelet signaling.” PMID 21502577 ↗ Apr 2011
1

“Atopaxar is a reversible protease-activated receptor-1 antagonist that interferes with thrombin-mediated platelet effects.” PMID 21502571 ↗ Apr 2011
Known as ATOPAXAR HYDROBROMIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL2103856 ↗
Known as E-5555 HBR ChEMBL registry synonym — accepted as the source's own label CHEMBL2103856 ↗
Known as E5555 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00548587 ↗
5

NCT00540670 ↗

NCT01241669 ↗

NCT01261156 ↗

NCT00312052 ↗

NCT00619164 ↗
Known as ER-172594-00 ChEMBL registry synonym — accepted as the source's own label CHEMBL2103856 ↗
Known as ER-172594-06 ChEMBL registry synonym — accepted as the source's own label CHEMBL2103856 ↗
Action Inhibit “Proteinase-activated receptor 1 antagonist” CHEMBL2103856 ↗
1

“a PAR-1 inhibitor” NCT00312052 ↗
Modality Small molecule — CHEMBL2103856 ↗
Route Oral “taken orally once daily” NCT00312052 ↗
Target F2R “Proteinase-activated receptor 1 antagonist” CHEMBL2103856 ↗