Drugs / Miglitol
last change Jun 2025 re-read 2 minutes ago

Miglitol

also known as BAY M 1099 · Diastabol · Glyset · NSC-758702

Small molecule targets GAA, MGAM via inhibition

Developed for
type 2 diabetes mellitus · type 1 diabetes mellitus
Investigated by
Sanwa Kagaku Kenkyusho Co., Ltd. · Astellas Pharma Inc

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) GLYSET 1999-08-16 fda.gov
Approved US (FDA) GLYSET 1996-12-18 fda.gov

Trials 7 · a red edge is where a trial was stopped

today
US approved 1996
NCT01099839 · Ph 1
1997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01099839 Feb → Apr 2010 Astellas Pharma Inc Completed No outcome recorded
Phase 36 trials
Phase 3 NCT00334399 type 2 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Phase 3 NCT00334503 type 2 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Phase 3 NCT00213070 type 2 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Phase 3 NCT00213109 type 1 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Phase 3 NCT00380822 type 2 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Phase 3 NCT00213122 type 2 diabetes mellitus Sanwa Kagaku Kenkyusho Co., Ltd. Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 31 trial
Phase 3 NCT01242202 Background Oct 2010 → May 2012 type 2 diabetes mellitus Astellas Pharma Inc Completed No outcome recorded
Phase 41 trial
Phase 4 NCT06449235 Comparator Sep 2024 → Apr 2025 overdue type 2 diabetes mellitus Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders Not yet recruiting No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Miglitol “Chemical Name: Alpha-Glucosidase Inhibitors (e.g., Acarbose, Miglitol) Class: Alpha-Glucosidase Inhibitors” NCT06449235
8

MiglitolNCT01242202

NCT01099839

NCT00213070

NCT00334399

NCT00213109

NCT00380822

NCT00334503

NCT00213122

Known as BAY M 1099 ChEMBL registry synonym — accepted as the source's own label CHEMBL1561
Known as Diastabol ChEMBL registry synonym — accepted as the source's own label CHEMBL1561
Known as Glyset ChEMBL registry synonym — accepted as the source's own label CHEMBL1561
Known as NSC-758702 ChEMBL registry synonym — accepted as the source's own label CHEMBL1561
Action Inhibit Inhibits alpha-glucosidase enzymes in the small intestine.” NCT06449235
2

“Lysosomal alpha-glucosidase inhibitor” CHEMBL1561

“Maltase-glucoamylase inhibitor” CHEMBL1561

Modality Small molecule CHEMBL1561
Route Oral “Administration: Administered orally, typically taken with the first bite of each main meal.” NCT06449235
Target GAA “Lysosomal alpha-glucosidase inhibitor” CHEMBL1561
Target MGAM “Maltase-glucoamylase inhibitor” CHEMBL1561