drugset

Drugs / Peg-Ada

Follow last change Sep 2022 re-read 2 minutes ago

Peg-Ada

English name pegademase bovine

also known as pegademase bovine

Protein / enzyme biologic

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	ADAGEN	—	1990-03-21	fda.gov ↗

Trials 0

Also used as a comparator or background therapy in 4 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/2	NCT03765632 Background	Jan 2018 → Sep 2021	severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency	Great Ormond Street Hospital for Children NHS Foundation Trust	Completed	No outcome recorded
Phase 1/2	NCT02999984 Background	Dec 2016 → Oct 2018	severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency	University of California, Los Angeles	Completed	No outcome recorded
Phase 1/2	NCT01852071 Background	Aug 2013 → Aug 2018	severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency	University of California, Los Angeles	Completed	No outcome recorded
Phase 1/2	NCT01380990 Background	Nov 2012 → Dec 2019	severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency	Great Ormond Street Hospital for Children NHS Foundation Trust	Completed	No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

Field	Value	Cited text
Known as	PEG-ADA	“pegademase bovine (PEG-ADA) Enzyme Replacement Therapy (ERT) is discontinued at Day+30 (-3/+15) after the transplant” NCT03765632 ↗ 4 “pegademase bovine (PEG-ADA) Enzyme Replacement Therapy (ERT) is discontinued at Day+30 (-3/+15) after the transplant” NCT02999984 ↗ “pegademase bovine (PEG-ADA) enzyme replacement therapy (ERT)” NCT01852071 ↗ NCT03765632 ↗ NCT01380990 ↗
Known as	pegademase bovine	“pegademase bovine (PEG-ADA) Enzyme Replacement Therapy (ERT) is discontinued at Day+30 (-3/+15) after the transplant” NCT03765632 ↗ 2 “pegademase bovine (PEG-ADA) Enzyme Replacement Therapy (ERT) is discontinued at Day+30 (-3/+15) after the transplant” NCT02999984 ↗ “pegademase bovine (PEG-ADA) enzyme replacement therapy (ERT)” NCT01852071 ↗
Modality	Protein / enzyme biologic	“Peg-Ada enzyme replacement therapy” NCT01380990 ↗