Drugs / Tozorakimab

Trials 16 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06908577 Apr → Nov 2025 AstraZeneca Completed No outcome recorded
Phase 1 NCT06304961 Apr → Sep 2024 AstraZeneca Completed No outcome recorded
Phase 1 NCT05070312 Aug 2021 → Feb 2022 AstraZeneca Completed No outcome recorded
Phase 1 NCT03096795 May 2017 → Sep 2019 chronic obstructive pulmonary disease MedImmune LLC Completed No outcome recorded
Phase 26 trials
Phase 2 NCT06897748 Apr 2025 → Apr 2026 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded
Phase 2 NCT06932263 Mar 2025 → Jun 2027 expected asthma AstraZeneca Recruiting No outcome recorded
Phase 2 NCT04631016 Dec 2020 → May 2023 chronic bronchitis AstraZeneca Completed No outcome recorded
Phase 2 NCT04570657 Sep 2020 → Dec 2022 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT04212169 Dec 2019 → Jul 2022 atopic eczema AstraZeneca Completed No outcome recorded
Phase 2 NCT04170543 Nov 2019 → May 2023 diabetic kidney disease AstraZeneca Completed No outcome recorded
Phase 36 trials
Phase 3 NCT07566195 May 2026 → Dec 2028 expected chronic obstructive pulmonary disease AstraZeneca Recruiting No outcome recorded
Phase 3 NCT06040086 Sep 2023 → Mar 2026 overdue chronic obstructive pulmonary disease AstraZeneca Active not recruiting No outcome recorded
Phase 3 NCT05742802 Mar 2023 → Feb 2026 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded
Phase 3 NCT05624450 Dec 2022 → Jun 2026 overdue acute respiratory failure AstraZeneca Recruiting No outcome recorded
Phase 3 NCT05158387 Feb 2022 → Jan 2026 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded
Phase 3 NCT05166889 Jan 2022 → Jan 2026 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2026-04-20 AstraZeneca Tozorakimab met primary endpoint in Phase III MIRANDA trial in patients with COPD astrazeneca.com
2026-03-27 AstraZeneca Tozorakimab met primary endpoint in both OBERON and TITANIA Phase III trials in patients with COPD astrazeneca.com

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 17 sources stand behind the page.

FieldValueCited text
Known as Tozorakimab “Therefore, FRONTIER-1 was designed to test the safety and efficacy of the IL-33-targeted monoclonal antibody tozorakimab in patients with DKD.” PMID 38899206 Mar 2024
11

NCT06304961

NCT04631016

NCT06932263

NCT05742802

NCT06040086

NCT05624450

NCT06897748

NCT07566195

NCT05158387

NCT06908577

NCT05166889

Known as MEDI3506 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04212169
3

NCT03096795

NCT04570657

NCT05070312

Action Inhibit Inhibition of IL-33 by tozorakimab was well tolerated” PMID 41563367 Dec 2025
Modality Monoclonal antibody “tozorakimab, an IL-33-neutralizing mAb” PMID 41563367 Dec 2025
Route Subcutaneous “Healthy participants with a history of mild atopy and proven sensitivity to HDM will receive a single MEDI3506 Dose 1 subcutaneously.” NCT03096795
Target IL33 “the IL-33-targeted monoclonal antibody tozorakimab” PMID 38899206 Mar 2024