Drugs / AB-1002
last change 3 days ago re-read 3 minutes ago

AB-1002

Gene therapy (AAV / viral vector)

Developed for
congestive heart failure
Investigated by
AskBio Inc

Trials 2

20202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04179643 Nov 2019 → Aug 2024 overdue cardiac rhythm disease, diastolic heart failure, ischemic disease, systolic heart failure AskBio Inc Active not recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT05598333 Oct 2023 → Oct 2026 expected congestive heart failure AskBio Inc Active not recruiting No outcome recorded

Press releases naming this drug 12 releases

DateIssuerRelease
2026-08-29 Bayer AskBio Presents Baseline Characteristics from Phase 2 Heart Failure Gene Therapy Trial of Umiposgene Parvec (AB-1002) at European Society of Cardiology Congress bayer.com ↗
2026-08-29 AskBio Inc AskBio Presents Baseline Characteristics from Phase 2 Heart Failure Gene Therapy Trial of Umiposgene Parvec (AB-1002) at European Society of Cardiology Congress askbio.com ↗
2026-04-01 Bayer AskBio Announces Completion of Enrollment in Phase 2 Clinical Trial of AB-1002 Investigational Gene Therapy for Heart Failure bayer.com ↗
2026-04-01 AskBio Inc AskBio Announces Completion of Enrollment in Phase 2 Clinical Trial of AB-1002 Investigational Gene Therapy for Heart Failure askbio.com ↗
2025-12-09 Bayer AskBio’s AB-1005 and AB-1002 Receive Pioneering Regenerative Medical Product Designation in Japan bayer.com ↗
2025-12-09 AskBio Inc AskBio’s AB-1005 and AB-1002 Receive Pioneering Regenerative Medical Product Designation in Japan askbio.com ↗
2025-10-21 Bayer AskBio Announces Publication in Nature Medicine of 12-month data from Phase 1 Trial of AB-1002 Gene Therapy in Participants with Congestive Heart Failure bayer.com ↗
2025-10-21 AskBio Inc AskBio Announces Publication in Nature Medicine of 12-month data from Phase 1 Trial of AB-1002 Gene Therapy in Participants with Congestive Heart Failure askbio.com ↗
2025-05-19 Bayer AskBio Presents Complete Results of Phase 1 Trial of AB-1002 Gene Therapy in Participants with Congestive Heart Failure at European Society of Cardiology Heart Failure Meeting bayer.com ↗
2025-05-19 AskBio Inc AskBio Presents Complete Results of Phase 1 Trial of AB-1002 Gene Therapy in Participants with Congestive Heart Failure at European Society of Cardiology Heart Failure Meeting askbio.com ↗
2024-04-18 Bayer AskBio receives FDA Fast Track Designation for AB-1002 investigational gene therapy program in congestive heart failure bayer.com ↗
2024-04-18 AskBio Inc AskBio receives FDA Fast Track Designation for AB-1002 investigational gene therapy program in congestive heart failure askbio.com ↗

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as AB-1002 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04179643 ↗
1

NCT05598333 ↗

Action Inhibit “delivers constitutively active protein phosphatase 1 inhibitor 1 to cardiomyocytes” PMID 41120766 ↗ Oct 2025
Modality Gene therapy (AAV / viral vector) “a chimeric cardiotropic adeno-associated viral vector” PMID 41120766 ↗ Oct 2025
Route Other “single intracoronary infusion of AB-1002” NCT04179643 ↗