Drugs / AMG 319
last change May 2018 re-read 3 minutes ago

AMG 319

also known as J3.391.906I

Small molecule targets PIK3CD via inhibition

Developed for
B-cell chronic lymphocytic leukemia · cancer · diffuse large B-cell lymphoma · head and neck squamous cell carcinoma · mantle cell lymphoma · T-cell non-Hodgkin lymphoma
Investigated by
Amgen · Cancer Research UK

Trials 2

20112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01300026 Apr 2011 → Oct 2013 B-cell chronic lymphocytic leukemia, T-cell non-Hodgkin lymphoma, cancer, diffuse large B-cell lymphoma +1 Amgen Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02540928 Oct 2015 → May 2018 head and neck squamous cell carcinoma, human papilloma virus infection Cancer Research UK Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as AMG 319 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01300026 ↗
1

NCT02540928 ↗

Known as J3.391.906I ChEMBL registry synonym — accepted as the source's own label CHEMBL4303596 ↗
Action Inhibit “PI3-kinase p110-delta subunit inhibitor” CHEMBL4303596 ↗
1

“small molecule inhibitor of PI3Kδ” NCT01300026 ↗

Modality Small molecule “small molecule inhibitor” NCT01300026 ↗
Route Oral “administered by mouth once daily” NCT01300026 ↗
Target PIK3CD “PI3-kinase p110-delta subunit inhibitor” CHEMBL4303596 ↗