Drugs / MRTX0902
last change Feb 2026 re-read 9 days ago

MRTX0902

also known as UNII-CRG69FR93G

Small molecule targets SOS1 via inhibition

Developed for
colorectal cancer · non-small cell lung carcinoma
Investigated by
Mirati Therapeutics Inc.

Trials 1

2023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT05578092 Dec 2022 → Feb 2026 colorectal cancer, non-small cell lung carcinoma Mirati Therapeutics Inc. Terminated No outcome recorded Stop: Business

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2024-03-05 Verastem, Inc. Results Verastem Oncology Announces Preclinical Presentations for New Oral G12D Inhibitor and for Avutometinib and Defactinib Combination as a Backbone of Therapy for RAS/MAPK Driven Cancers at AACR Annual Meeting 2024 verastem.com ↗
The SOS1 Inhibitor MRTX0902 Demonstrates Activity Across Cancer Models with Mutations in Proximal Components of the RAS-MAPK pathway

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as MRTX0902 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05578092 ↗
Known as UNII-CRG69FR93G ChEMBL registry synonym — accepted as the source's own label CHEMBL5192659 ↗
Action Inhibit “SOS1 inhibitor” NCT05578092 ↗
Modality Small molecule — CHEMBL5192659 ↗
Target SOS1 “SOS1 inhibitor” NCT05578092 ↗