Drugs / OLODANRIGAN
last change Oct 2021 re-read 3 minutes ago

OLODANRIGAN

also known as EMA401 · PD-126055

Small molecule targets AGTR2 via inhibition

Developed for
postherpetic neuralgia · diabetic neuropathy · diabetic polyneuropathy
Investigated by
Novartis Pharmaceuticals · Spinifex Pharmaceuticals Pty Ltd · Syneos Health

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT03297294 Mar 2018 → Mar 2019 diabetic polyneuropathy Novartis Pharmaceuticals Terminated Missed primary
Phase 2 NCT03094195 Jun 2017 → Mar 2019 postherpetic neuralgia Novartis Pharmaceuticals Terminated Missed primary
Phase 2 NCT02426411 Jun 2015 → Oct 2016 postherpetic neuralgia Spinifex Pharmaceuticals Pty Ltd Withdrawn No outcome recorded
Phase 2 NCT02435199 Jun 2015 → Oct 2016 diabetic neuropathy Spinifex Pharmaceuticals Pty Ltd Withdrawn No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as OLODANRIGAN ChEMBL registry synonym — accepted as the source's own label CHEMBL34124 ↗
Known as EMA401 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02426411 ↗
3

NCT03094195 ↗

NCT03297294 ↗

NCT02435199 ↗

Known as PD-126055 ChEMBL registry synonym — accepted as the source's own label CHEMBL34124 ↗
Action Inhibit “EMA401 (a highly selective angiotensin II type 2 receptor antagonist)” PMID 33675631 ↗ Oct 2021
1

“Angiotensin II type 2 (AT-2) receptor antagonist” CHEMBL34124 ↗

Modality Small molecule — CHEMBL34124 ↗
Route Oral “Ema401 25 mg was administered orally twice a day” NCT03094195 ↗
Target AGTR2 “Angiotensin II type 2 (AT-2) receptor antagonist” CHEMBL34124 ↗