Mazindol

also known as 42-548 · AN-448 · Magrilon · Mazanor · Mazildene · Mazindol civ · SAH-42548 · Sanorex · +2 more

Developed for: attention deficit-hyperactivity disorder · cocaine abuse · narcolepsy without cataplexy · narcolepsy-cataplexy syndrome
Investigated by: NLS Pharmaceutics · National Institute on Drug Abuse (NIDA) · VA Connecticut Healthcare System · Yale University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	SANOREX	—	1973-06-14	fda.gov ↗

Trials 3

today

US approved 1973

NCT05055024 · Ph 2 NCT02808104 · Ph 2 NCT00000277 · Ph 2

197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 23 trials
Phase 2	NCT05055024	Oct 2021 → Jan 2023	narcolepsy without cataplexy, narcolepsy-cataplexy syndrome	NLS Pharmaceutics	Completed	No outcome recorded
Phase 2	NCT02808104	Aug 2016 → Mar 2017	attention deficit-hyperactivity disorder	NLS Pharmaceutics	Completed	No outcome recorded
Phase 2	NCT00000277	Sep 1994 → Aug 1999	cocaine abuse	Yale University	Completed	No outcome recorded
Comparator or background therapy1 trial
Phase 2	NCT04923594 Comparator	Sep 2021 → Jun 2022	narcolepsy-cataplexy syndrome	NLS Pharmaceutics	Completed	No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

Field	Value	Cited text
Known as	mazindol	ClinicalTrials.gov intervention name — accepted as the source's own label NCT04923594 ↗ 3 NCT05055024 ↗ NCT02808104 ↗ NCT00000277 ↗
Known as	42-548	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	AN-448	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Magrilon	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Mazanor	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Mazildene	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Mazindol civ	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	SAH-42548	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Sanorex	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Terenac	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Known as	Teronac	ChEMBL registry synonym — accepted as the source's own label CHEMBL781 ↗
Modality	Small molecule	— CHEMBL781 ↗
Route	Oral	“adult subjects with ADHD will be randomized to either oral mazindol controlled release or placebo once daily.” NCT02808104 ↗