Drugs / Talsaclidine
last change Sep 2000 re-read 2 minutes ago

Talsaclidine

Small molecule targets CHRM1, CHRM2, CHRM3 via activation

Developed for
Alzheimer disease
Investigated by
Boehringer Ingelheim

Trials 7 · a red edge is where a trial was stopped

199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT02264093 Nov 1999 → Feb 2000 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02264080 Mar 1999 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02264054 Feb → Mar 1999 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02264067 Jul → Nov 1998 Boehringer Ingelheim Completed No outcome recorded
Phase 22 trials
Phase 2 NCT02249351 Dec 1999 → May 2000 Alzheimer disease Boehringer Ingelheim Terminated No outcome recorded
Phase 2 NCT02249403 Jan 1999 → Jan 2000 Alzheimer disease Boehringer Ingelheim Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02248116 May 1999 → Sep 2000 Alzheimer disease Boehringer Ingelheim Terminated No outcome recorded

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Talsaclidine ClinicalTrials.gov intervention name — accepted as the source's own label NCT02264067
5

NCT02249403

NCT02264054

NCT02248116

NCT02249351

NCT02264093

Known as [14C]talsaclidine “Drug: [14C]talsaclidine, oral” NCT02264054
Known as Talsaclidina ChEMBL registry synonym — accepted as the source's own label CHEMBL2111051
Known as Talsaclidine (Free Base) “Efficacy and Safety of 6, 12, 24, and 36 mg Tid po and 36 mg Bid po Talsaclidine (Free Base) for 12 Weeks” NCT02249403
Known as talsaclidine base “symptomatic efficacy of talsaclidine base on ADAScog” NCT02249403
Known as TALSACLIDINE FUMARATE ChEMBL registry synonym — accepted as the source's own label CHEMBL2111051
Known as WAL 2014 FU ChEMBL registry synonym — accepted as the source's own label CHEMBL2111051
Known as WAL2014 “Pharmacokinetics and Safety of WAL2014 (Talsaclidine) in Healthy Male Volunteers” NCT02264067
1

NCT02264080

Action Activate “Muscarinic acetylcholine receptor M3 partial agonist” CHEMBL2111051
2

“Muscarinic acetylcholine receptor M2 partial agonist” CHEMBL2111051

“Muscarinic acetylcholine receptor M1 agonist” CHEMBL2111051

Modality Small molecule CHEMBL2111051
Route Oral Oral Administration” NCT02248116
Target CHRM1 “Muscarinic acetylcholine receptor M1 agonist” CHEMBL2111051
Target CHRM2 “Muscarinic acetylcholine receptor M2 partial agonist” CHEMBL2111051
Target CHRM3 “Muscarinic acetylcholine receptor M3 partial agonist” CHEMBL2111051